Cell apoptosis, autophagy and necroptosis in osteosarcoma treatment

被引：92

作者：

Li, Jing ^{[1
,2
]}

Yang, Zuozhang ^{[1
]}

Li, Yi ^{[3
]}

Xia, Junfeng ^{[1
]}

Li, Dongqi ^{[1
]}

Li, Huiling ^{[1
]}

Ren, Mingyan ^{[1
]}

Liao, Yedan ^{[1
]}

Yu, Shunling ^{[1
]}

Chen, Yanjin ^{[1
]}

Yang, Yihao ^{[1
]}

Zhang, Ya ^{[1
]}

机构：

[1] Kunming Med Univ, Tumor Hosp Yunnan Prov, Bone & Soft Tissue Tumors Res Ctr Yunnan Prov, Dept Orthopaed,Affiliated Hosp 3, Kunming, Yunnan, Peoples R China

[2] Peking Univ, Coll Life Sci, State Key Lab Prot & Plant Gene Res, Beijing, Peoples R China

[3] Kunming Gen Hosp Chengdu Mil Command, Dept Oncol, Kunming, Yunnan, Peoples R China

来源：

ONCOTARGET | 2016年 / 7卷 / 28期

基金：

中国博士后科学基金; 中国国家自然科学基金;

关键词：

apoptosis; autophagy; necroptosis; chemotherapy resistance; osteosarcoma; CELASTROL INDUCES APOPTOSIS; PROTEIN-KINASE; LUNG METASTASIS; IN-VITRO; PROTEASOME INHIBITOR; MEDIATED AUTOPHAGY; SIGNALING PATHWAY; DRUG-RESISTANCE; DOWN-REGULATION; DEATH RECEPTOR;

D O I：

10.18632/oncotarget.8206

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Osteosarcoma is the most common primary bone tumor in children and adolescents. Although combined therapy including surgery and multi-agent chemotherapy have resulted in great improvements in the overall survival of patients, chemoresistance remains an obstacle for the treatment of osteosarcoma. Molecular targets or effective agents that are actively involved in cell death including apoptosis, autophagy and necroptosis have been studied. We summarized how these agents (novel compounds, miRNAs, or proteins) regulate apoptotic, autophagic and necroptotic pathways; and discussed the current knowledge on the role of these new agents in chemotherapy resistance in osteosarcoma.

引用

页码：44763 / 44778

页数：16