THE MECHANISM OF P22PHOX C242T SNP INHIBITION OF TNF ALPHA-INDUCED NOX2 ACTIVATION IN HUMAN ENDOTHELIAL CELLS AND VESSELS

被引：0
|
作者：
Meijles, Daniel [1 ]
Fan, Lampson [2 ]
Ghazaly, Maziah [3 ]
Li, Jian-Mei [1 ]
机构：
[1] Univ Reading, Reading RG6 2AH, Berks, England
[2] Royal Berkshire Hosp, Reading RG1 5AN, Berks, England
[3] Univ Surrey, Guildford GU2 5XH, Surrey, England
来源：
HEART | 2016年 / 102卷
关键词：
D O I：
10.1136/heartjnl-2016-309890.167
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
167
引用
收藏
页码：A117 / A118
页数：3
相关论文
共 20 条
  • [1] Mechanisms of p22Phox C242T Polymorphism in Reduced TNF Alpha-Induced Nox2 Activation in Endothelial Cells
    Meijles, Daniel N.
    Li, Jian-Mei
    CIRCULATION, 2012, 126 (21)
  • [2] p22phox C242T Single-Nucleotide Polymorphism Inhibits Inflammatory Oxidative Damage to Endothelial Cells and Vessels
    Meijles, Daniel N.
    Fan, Lampson M.
    Ghazaly, Maziah M.
    Howlin, Brendan
    Kroenke, Martin
    Brooks, Gavin
    Li, Jian-Mei
    CIRCULATION, 2016, 133 (24) : 2391 - +
  • [3] Relationship of p22phox C242T polymorphism with nephropathy in type 2 diabetic patients
    Santos, KG
    Canani, LH
    Gross, JL
    Tschiedel, B
    Souto, KE
    Roisenberg, I
    JOURNAL OF NEPHROLOGY, 2005, 18 (06) : 733 - 738
  • [4] Relationship of the C242T p22phox gene polymorphism to angiographic coronary artery disease and endothelial function
    Li, A
    Prasad, A
    Mincemoyer, R
    Satorius, C
    Epstein, N
    Finkel, T
    Quyyumi, AA
    AMERICAN JOURNAL OF MEDICAL GENETICS, 1999, 86 (01): : 57 - 61
  • [5] The C242T p22phox polymorphism of the NADPH oxidase is associated with reduced superoxide production in human neutrophils
    Wyche, KE
    Griendling, KK
    Dikalov, SI
    Austin, H
    Sorescu, D
    Harrison, DG
    Zafarl, AM
    CIRCULATION, 2001, 104 (17) : 40 - 40
  • [6] BIOINFORMATIC IMAGING AND MOLECULAR INVESTIGATION FOR A ROLE OF P22PHOX C242T POLYMORPHISM IN INHIBITING ENDOTHELIAL ROS PRODUCTION
    Meijles, D. N.
    Howlin, B. J.
    Li, J-M
    HEART, 2012, 98 : A68 - A69
  • [7] Interaction of P22phox with NOX2 or NOX4 results in ROS production and proliferation of endothelial cells
    Djordjevic, T
    Petry, A
    Bickel, C
    Bonello, S
    BelAiba, R
    Acker, H
    Pfeilschifter, J
    Gorlach, A
    CIRCULATION, 2004, 110 (17) : 284 - 284
  • [8] p40phox as an alternative organizer to p47phox in Nox2 activation:: A new mechanism involving an interaction with p22phox
    Tamura, Minoru
    Shiozaki, Lichiro
    Ono, Shohei
    Miyano, Kei
    Kunihiro, Sachio
    Sasaki, Takayuki
    FEBS LETTERS, 2007, 581 (23) : 4533 - 4538
  • [9] Functional effects of NAD(P)H oxidase p22phox C242T mutation in human leukocytes and association with thrombotic cerebral infarction
    Shimo-Nakanishi, Y
    Hasebe, T
    Suzuki, A
    Mochizuki, H
    Nomiyama, T
    Tanaka, Y
    Nagaoka, I
    Mizuno, Y
    Urabe, T
    ATHEROSCLEROSIS, 2004, 175 (01) : 109 - 115
  • [10] C242T polymorphism of the NADPH oxidase p22PHOX gene and its association with endothelial dysfunction in asymptomatic individuals with essential systemic hypertension
    Rafiq, Adnan
    Aslam, Khursheed
    Malik, Rouf
    Afroze, Dil
    MOLECULAR MEDICINE REPORTS, 2014, 9 (05) : 1857 - 1862
12