Nucleophilic Deoxyfluorination of Catechols

被引：33
|
作者：
Nemoto, Hiroyuki [1 ]
Nishiyama, Tsuyoshi [1 ]
Akai, Shuji [1 ]
机构：
[1] Univ Shizuoka, Sch Pharmaceut Sci, Suruga Ku, Shizuoka 4228526, Japan
来源：
ORGANIC LETTERS | 2011年 / 13卷 / 10期
关键词：
SPECTRUM DEOXOFLUORINATING AGENT; ENHANCED THERMAL-STABILITY; BIS(2-METHOXYETHYL)AMINOSULFUR TRIFLUORIDE; MEDICINAL CHEMISTRY; ARYL FLUORIDES; FLUORINATION; DOPAMINE; PROTECTION; CONVERSION; SOLVENT;
D O I：
10.1021/ol200808q
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Nucleophilic deoxyfluorinalton of one of the two hydroxyl groups of catechols has been developed via the Umpolung concept. This method was successively applied to naturally occurring catechols, such as catechins and dopamine, to produce novel fluorinated analogues.
引用
收藏
页码：2714 / 2717
页数：4
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