Plumericin inhibits the viability of cervical cancer cells by induction of apoptosis through degradation of DNA structure

The current study demonstrates the effect of plumericin on the viability and induction of apoptosis through degradation of dottble helical DNA structure in Bu25TK and HeLa cervical carcinoma cell lines. Plumeridri treatment exhibited concentration-and time-dependent effect on the viability of Bu25TK and HeLa cells, Incubation of Bu25TK and HeLa cells with 40 !AM concentration of plumericin &creased cell viability to 24 and 29%, respectively after 48 hours. Plumericin treatment also caused significant increase in the proportion of apoptotic cells in both the cell lines at 40 !AM concentration compared to the control cells. Examination of the DNA double helical structure after 48 hours of treatment with Plumericin at 40 JIM concentration showed DNA degradation and formation of comets. Thus, plumericin exhibits inhibitory effect on the viability of Bu25TK and HeLa cells and irtduced apoptosis through DNA degradation. Therefore, plumericin is a potent candidate for the treatment of cervical carcinoma.