Reparation and Immunomodulating Properties of Bacillus sp. Metabolites from Permafrost

被引：1
|
作者：
Kalenova, L. F. [1 ,3 ]
Melnikov, V. P. [1 ,2 ,3 ]
Besedin, I. M. [3 ]
Bazhin, A. S. [3 ]
Gabdulin, M. A. [3 ]
Kolyvanova, S. S. [1 ,3 ]
机构：
[1] Tyumen State Univ, Tyumen, Russia
[2] Tyumen Ind Univ, Tyumen, Russia
[3] Russian Acad Sci, Tyumen Sci Ctr, Siberian Div, Tyumen, Russia
来源：
BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE | 2017年 / 163卷 / 05期
关键词：
microorganisms of permafrost; temperature; metabolites; immunomodulators; MICROORGANISMS; REPAIR;
D O I：
10.1007/s10517-017-3875-y
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
An ointment containing metabolites of Bacillus sp. microorganisms isolated from permafrost samples was applied onto the skin wound of BALB/c mice. Metabolites isolated during culturing of Bacillus sp. at 37A degrees C produced a potent therapeutic effect and promoted wound epithelialization by 30% in comparison with the control (ointment base) and by 20% in comparison with Solcoseryl. Treatment with Bacillus sp. metabolites stimulated predominantly humoral immunity, reduced the time of wound contraction and the volume of scar tissue, and promoted complete hair recovery. These metabolites can be considered as modulators of the wound process with predominance of regeneration mechanisms.
引用
收藏
页码：667 / 670
页数：4
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