Modernizing Human Cancer Risk Assessment of Therapeutics

被引：18
|
作者：
Fielden, Mark R. [1 ]
Ward, Lucas D. [1 ]
Minocherhomji, Sheroy [1 ]
Nioi, Paul [1 ]
Lebrec, Herve [1 ]
Jacobson-Kram, David [2 ]
机构：
[1] Amgen Inc, One Amgen Ctr Dr, Thousand Oaks, CA 91320 USA
[2] ToxRox Consulting, Mclean, VA USA
来源：
TRENDS IN PHARMACOLOGICAL SCIENCES | 2018年 / 39卷 / 03期
关键词：
GENOME-WIDE ASSOCIATION; GROWTH-FACTOR-I; CLONAL HEMATOPOIESIS; DNA-REPAIR; INSTABILITY; PREDICTION; MUTATIONS; LIVER; STRESS; CARCINOGENICITY;
D O I：
10.1016/j.tips.2017.11.005
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Cancer risk assessment of therapeutics is plagued by poor translatability of rodent models of carcinogenesis. In order to overcome this fundamental limitation, new approaches are needed that enable us to evaluate cancer risk directly in humans and human-based cellular models. Our enhanced understanding of the mechanisms of carcinogenesis and the influence of human genome sequence variation on cancer risk motivates us to re-evaluate how we assess the carcinogenic risk of therapeutics. This review will highlight new opportunities for applying this knowledge to the development of a battery of human-based in vitro models and biomarkers for assessing cancer risk of novel therapeutics.
引用
收藏
页码：232 / 247
页数：16
相关论文
共 50 条
  • [1] QUANTITATIVE ASSESSMENT OF HUMAN CANCER RISK
    KALDOR, JM
    SCANDINAVIAN JOURNAL OF WORK ENVIRONMENT & HEALTH, 1992, 18 : 90 - 96
  • [2] Minimizing Risk of Cancer Therapeutics
    Clark, Megan
    PHYSICAL MEDICINE AND REHABILITATION CLINICS OF NORTH AMERICA, 2018, 29 (04) : 701 - 719
  • [3] Immunogenicity Risk Assessment for PEGylated Therapeutics
    Johanna R. Mora
    Joleen T. White
    Stephen L. DeWall
    The AAPS Journal, 22
  • [4] Immunogenicity Risk Assessment for PEGylated Therapeutics
    Mora, Johanna R.
    White, Joleen T.
    DeWall, Stephen L.
    AAPS JOURNAL, 2020, 22 (02):
  • [5] THE WILDLIFE HUMAN CONNECTION - MODERNIZING RISK-DECISIONS
    COLBORN, T
    ENVIRONMENTAL HEALTH PERSPECTIVES, 1994, 102 : 55 - 59
  • [6] Modernizing risk assessment: A systematic integration of PRA and PHM techniques
    Moradi, Ramin
    Groth, Katrina M.
    RELIABILITY ENGINEERING & SYSTEM SAFETY, 2020, 204
  • [7] Moving Forward in Human Cancer Risk Assessment
    Paules, Richard S.
    Aubrecht, Jiri
    Corvi, Raffaella
    Garthoff, Bernward
    Kleinjans, Jos C.
    ENVIRONMENTAL HEALTH PERSPECTIVES, 2011, 119 (06) : 739 - 743
  • [8] Germline BRCA testing is moving from cancer risk assessment to a predictive biomarker for targeting cancer therapeutics
    Moreno, L.
    Linossi, C.
    Esteban, I.
    Gadea, N.
    Carrasco, E.
    Bonache, S.
    Gutierrez-Enriquez, S.
    Cruz, C.
    Diez, O.
    Balmana, J.
    CLINICAL & TRANSLATIONAL ONCOLOGY, 2016, 18 (10): : 981 - 987
  • [9] Germline BRCA testing is moving from cancer risk assessment to a predictive biomarker for targeting cancer therapeutics
    L. Moreno
    C. Linossi
    I. Esteban
    N. Gadea
    E. Carrasco
    S. Bonache
    S. Gutiérrez-Enríquez
    C. Cruz
    O. Díez
    J. Balmaña
    Clinical and Translational Oncology, 2016, 18 : 981 - 987
  • [10] MODERNIZING DIETARY ASSESSMENT
    Garcia Perez, Isabel
    Posma, Joram M.
    Gibson, Rachel
    Chambers, Edward S.
    Nicholson, Jeremy K.
    Holmes, Elaine
    Frost, Gary
    ANNALS OF NUTRITION AND METABOLISM, 2017, 71 : 286 - 287
12345