Polyethylene Glycol (PEG-400) as an Efficient and Recyclable Reaction Medium for the One-Pot Synthesis of N-Substituted Azepines under Catalyst-Free Conditions

被引：14

作者：

Mallepalli, Raghu ^{[2
]}

Yeramanchi, Lingappa ^{[2
]}

Bantu, Rajashaker ^{[1
]}

Nagarapu, Lingaiah ^{[1
]}

机构：

[1] Indian Inst Chem Technol, Organ Chem Div 2, Hyderabad 500607, Andhra Pradesh, India

[2] Sri Venkateswara Univ, Dept Chem, Tirupati 517502, Andhra Pradesh, India

来源：

SYNLETT | 2011年 / 18期

关键词：

anilines; dialkylacetylene dicarboxylates; 2,5-dimethoxytetrahydrofuran; N-substituted azepines; polyethylene glycol; catalyst-free conditions; FALCIPARUM FOOD VACUOLE; ALPHA(2)-ADRENOCEPTOR; METHYLTRANSFERASE; PLASMEPSINS; INHIBITORS; SITE;

D O I：

10.1055/s-0031-1289542

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Polyethylene glycol (PEG) was found to be an inexpensive nontoxic and effective medium for the one-pot synthesis of N-substituted azepines under catalyst-free conditions in excellent yields. Environmental acceptability, low cost, high yields, and recyclability of the PEG are the important features of this protocol.

引用

页码：2730 / 2732

页数：3

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