Acute Promyelocytic Leukemia: New treatment strategies with ATRA and ATO - AML-BFM-Recommendations

被引：8
|
作者：
Creutzig, Ursula [1 ]
Dworzak, Michael [2 ,3 ]
von Neuhoff, Nils [4 ]
Rasche, Mareike [4 ]
Reinhardt, Dirk [4 ]
机构：
[1] Hannover Med Sch Hannover, Pediat Hematol Oncol, Hannover, Germany
[2] St Anna Childrens Hosp, Vienna, Austria
[3] Med Univ Vienna, Childrens Canc Res Inst, Vienna, Austria
[4] Univ Hosp Essen, Dept Pediat Hematol Oncol, Pediat 3, Essen, Germany
来源：
KLINISCHE PADIATRIE | 2018年 / 230卷 / 06期
关键词：
acute promyelocytic leukemia; children; ATRA; Arsenic; TRANS-RETINOIC ACID; ACUTE MYELOGENOUS LEUKEMIA; AGENT ARSENIC TRIOXIDE; RISK GROUPS; FOLLOW-UP; CHILDHOOD; CHILDREN; THERAPY; TRIAL; CHEMOTHERAPY;
D O I：
10.1055/a-0750-5963
中图分类号：
R72 [儿科学];
学科分类号：
100202 ;
摘要：
The treatment of acute promyelocytic leukemia (APL) has changed significantly in recent years. Today, APL patients with standard risk (also known as low risk) can be treated chemotherapyfree only with all-trans-retinoic acid (ATRA) and arsenic trioxide (ATO). For high-risk patients, induction chemotherapy should be added. The curative results are good and comparable to those achieved in the past with chemotherapy plus ATRA. However, toxicities, especially infectious complications, are reduced. The main risk remains early lethal bleeding. Timely diagnosis and early ATRA treatment can reduce this risk. This review presents and discusses current treatment strategies and recommendations for APL in children.
引用
收藏
页码：299 / 304
页数：6
相关论文
共 50 条
  • [1] A novel approach to the treatment of ATRA/ATO resistant acute promyelocytic leukemia
    Chale, Ravinder S.
    Almeida, Stephanie M.
    Jozic, Ivan
    Schally, Andrew V.
    Jimenez, Joaquin J.
    CANCER RESEARCH, 2022, 82 (12)
  • [2] Successful Treatment of Recurrent Pericarditis With Rilonacept in the Setting Of ATRA/ATO Use in Acute Promyelocytic Leukemia
    Majid, Muhammad
    Arockiam, Aro Daniela
    Agrawal, Ankit
    Kumar, Ashwin
    Yaker, Zachary
    Mudra, Sarah
    Klein, Allan L.
    CIRCULATION, 2023, 148
  • [3] ATRA(ouble) in the treatment of acute promyelocytic leukemia
    Ozpolat, B
    Lopez-Berestein, G
    Mehta, K
    JOURNAL OF BIOLOGICAL REGULATORS AND HOMEOSTATIC AGENTS, 2001, 15 (02): : 107 - 122
  • [4] Allogeneic stem cell transplantation for advanced acute promyelocytic leukemia in the ATRA and ATO era
    Ramadan, Safaa M.
    Di Veroli, Ambra
    Camboni, Agnese
    Breccia, Massimo
    Iori, Anna Paola
    Aversa, Franco
    Cupelli, Luca
    Papayannidis, Cristina
    Bacigalupo, Andrea
    Arcese, William
    Lo-Coco, Francesco
    HAEMATOLOGICA-THE HEMATOLOGY JOURNAL, 2012, 97 (11): : 1731 - 1735
  • [5] Treatment of acute promyelocytic leukemia in children: arsenic or ATRA
    Ravindranath, Y
    Gregory, J
    Feusner, J
    LEUKEMIA, 2004, 18 (10) : 1576 - 1577
  • [6] Treatment of acute promyelocytic leukemia in children: arsenic or ATRA
    Y Ravindranath
    J Gregory
    J Feusner
    Leukemia, 2004, 18 : 1576 - 1577
  • [7] The Combination of Gefitinib With ATRA and ATO Induces Myeloid Differentiation in Acute Promyelocytic Leukemia Resistant Cells
    de Almeida, Luciana Yamamoto
    Pereira-Martins, Diego A.
    Weinhaeuser, Isabel
    Ortiz, Cesar
    Candido, Larissa A.
    Lange, Ana Paula
    De Abreu, Nayara F.
    Mendonza, Silvia E. S.
    de Deus Wagatsuma, Virginia M.
    Do Nascimento, Mariane C.
    Paiva, Helder H.
    Alves-Paiva, Raquel M.
    Bonaldo, Camila C. O. M.
    Nascimento, Daniele C.
    Alves-Filho, Jose C.
    Scheucher, Priscila S.
    Lima, Ana Silvia G.
    Schuringa, Jan Jacob
    Ammantuna, Emanuele
    Ottone, Tiziana
    Noguera, Nelida I.
    Araujo, Cleide L.
    Rego, Eduardo M.
    FRONTIERS IN ONCOLOGY, 2021, 11
  • [8] Challenging Management of Severe Differentiation Syndrome in Pediatric Acute Promyelocytic Leukemia Treated with ATRA/ATO
    Molinaro, Alessandro
    Zanta, Daniela
    Moleti, Maria Luisa
    Giona, Fiorina
    Conter, Valentino
    Rizzari, Carmelo
    Biondi, Andrea
    Testi, Anna Maria
    MEDITERRANEAN JOURNAL OF HEMATOLOGY AND INFECTIOUS DISEASES, 2022, 14
  • [9] Prolonged treatment with arsenic trioxide (ATO) and all-trans-retinoic acid (ATRA) for relapsed acute promyelocytic leukemia previously treated with ATRA and chemotherapy
    Laura Cicconi
    Massimo Breccia
    Luca Franceschini
    Roberto Latagliata
    Matteo Molica
    Mariadomenica Divona
    Daniela Diverio
    Manuela Rizzo
    Tiziana Ottone
    Licia Iaccarino
    Valentina Alfonso
    Robin Foa
    Maria Teresa Voso
    Francesco Lo-Coco
    Annals of Hematology, 2018, 97 : 1797 - 1802
  • [10] ATRA and intensified double induction therapy in acute promyelocytic leukemia:: Strategies and results of the German AML Cooperative Group (AMLCG)
    Lengfelder, E.
    Buechner, T. H.
    ANNALS OF HEMATOLOGY, 2006, 85 : 82 - 84
12345