Formation of steady compound cone-jet modes and multilayered droplets in a tri-axial capillary flow focusing device

被引:32
|
作者
Si, Ting [1 ,2 ,3 ]
Feng, Hanxin [3 ]
Luo, Xisheng [1 ]
Xu, Ronald X. [2 ,3 ]
机构
[1] Univ Sci & Technol China, Dept Modern Mech, Hefei 230026, Peoples R China
[2] Ohio State Univ, Dept Biomed Engn, Columbus, OH 43210 USA
[3] Univ Sci & Technol China, Ctr Biomed Engn, Hefei 230026, Peoples R China
关键词
Flow focusing; Cone-jet mode; Tri-axial needle; Microencapsulation; Multilayered droplet; LIQUID; MICROPARTICLES; NANOPARTICLES; FUTURE; SINGLE;
D O I
10.1007/s10404-014-1486-8
中图分类号
TB3 [工程材料学];
学科分类号
0805 ; 080502 ;
摘要
A novel method for forming steady cone-jet modes and multilayered droplets is developed based on capillary flow focusing geometry using tri-axial needles. The needles manufactured by a laser beam welding process can be readily cleaned, assembled and aligned. A tri-axial capillary flow focusing (TCFF) device is assembled in order to focus a combination of different liquids in the core of a high-speed gas stream co-flowing through a small orifice. The effects of main control process parameters on the characteristics of compound cone-jet mode are studied. Under appropriate working conditions, steady cone-jet configurations with three layers of liquids are obtained, resulting in multilayered droplets with outer shell, middle layer and inner core. The process can also produce monodisperse droplets at smaller scales by releasing the outer shell and the middle liquid. The new design of tri-axial needles and TCFF devices enables reliable encapsulation of multiple components in one shell for potential applications in multimodal imaging, drug delivery, material processing and biomedicine.
引用
收藏
页码:967 / 977
页数:11
相关论文
共 9 条
  • [1] Formation of steady compound cone-jet modes and multilayered droplets in a tri-axial capillary flow focusing device
    Ting Si
    Hanxin Feng
    Xisheng Luo
    Ronald X. Xu
    Microfluidics and Nanofluidics, 2015, 18 : 967 - 977
  • [2] Operational modes of dual-capillary electrospraying and the formation of the stable compound cone-jet mod
    Mei, Fan
    Chen, Da-Ren
    AEROSOL AND AIR QUALITY RESEARCH, 2008, 8 (02) : 218 - 232
  • [3] Steady cone-jet mode in compound-fluidic electro-flow focusing for fabricating multicompartment microcapsules
    Si, Ting
    Yin, Chuansheng
    Gao, Peng
    Li, Guangbin
    Ding, Hang
    He, Xiaoming
    Xie, Bin
    Xu, Ronald X.
    APPLIED PHYSICS LETTERS, 2016, 108 (02)
  • [4] Dynamic Behaviours of Monodisperse Double Emulsion Formation in a Tri-Axial Capillary Device
    Dai, Yuchen
    Cha, Haotian
    Nguyen, Nhat-Khuong
    Ouyang, Lingxi
    Galogahi, Fariba
    Yadav, Ajeet Singh
    An, Hongjie
    Zhang, Jun
    Ooi, Chin Hong
    Nguyen, Nam-Trung
    MICROMACHINES, 2022, 13 (11)
  • [5] One-step production of multilayered microparticles by tri-axial electro-flow focusing
    Si, Ting
    Feng, Hanxin
    Li, Yang
    Luo, Xisheng
    Xu, Ronald
    REPORTERS, MARKERS, DYES, NANOPARTICLES, AND MOLECULAR PROBES FOR BIOMEDICAL APPLICATIONS VI, 2014, 8956
  • [6] Revision of capillary cone-jet physics: Electrospray and flow focusing (vol 79, 066305, 2009)
    Ganan-Calvo, Alfonso M.
    Montanero, Jose M.
    PHYSICAL REVIEW E, 2009, 79 (06):
  • [7] Breakup of compound jets with inner droplets in a capillary flow-focusing device
    Wang, Ju
    Liu, Zhaomiao
    Pang, Yan
    Li, Mengqi
    Zhou, Qiang
    PHYSICS OF FLUIDS, 2021, 33 (01)
  • [8] Design and fabrication of tri-axial capillary needles in flow focusing for microencapsulation of multiple drugs and imaging agents
    Si, Ting
    Feng, Hanxin
    Xie, Bin
    Xu, Ronald
    MICROFLUIDICS, BIOMEMS, AND MEDICAL MICROSYSTEMS XII, 2014, 8976
  • [9] One-step fabrication of triple-layered microcapsules by a tri-axial flow focusing device for microencapsulation of soluble drugs and imaging
    Yuan, Shuai
    Wu, Qiang
    Li, Guangbin
    Lei, Fan
    Si, Ting
    Xu, Ronald X.
    IMAGING, MANIPULATION, AND ANALYSIS OF BIOMOLECULES, CELLS, AND TISSUES IX, 2016, 9711