Epidemiology of benign essential blepharospasm: A nationwide population-based retrospective study in Taiwan

Importance This study provides a nationwide, population-based data on the incidence of benign essential blepharospasm in Asian adults. Background To describe the incidence, patient demographics, and risk factors associated with benign essential blepharospasm. Design Population-based retrospective study. Participants and samples A total of 1325 patients with benign essential blepharospasm were identified. Methods Patients with diagnosis of blepharopsasm between January 2000 and December 2013 were sampled using the Longitudinal Health Insurance Database 2000. Secondary blepharospasm that may be related to neurological, trauma, and ocular surface disease were excluded. Main outcome measured Multivariate conditional logistic regression was used to estimate the odds ratios for potential risk factors of benign essential blepharospasm. Results The mean annual incidence was 0.10% (0.07% for males, and 0.12% for females). The peak incidence was in the 50 to 59-year-old age group (0.19%). People living in urban regions have more risk of developing blepharospasm comparing to people living in less urban regions (p < 0.01). White-collar workers also have higher chance of having blepharospasm (p<0.001). Significant difference between control group and case group in hyperlipidemia (p <0.001), sleep disorders (p <0.001), mental disorders (depression, anxiety, obsessive compulsive disorder) (p <0.001), dry eye-related diseases (dry eye, Sjogren's syndrome) (p < 0.001), Parkinson's disease (p <0.004), and rosacea (p <0.021) were also identified. Conclusions and relevance Higher level of urbanization, white-collar work, sleep disorders, mental health diseases, dry eye-related diseases, Parkinsonism, and rosacea are possible risk factors for benign essential blepharospasm.