Emergence of OXA-48-Type Carbapenemase-Producing Enterobacteriaceae in German Hospitals

被引：73
|
作者：
Pfeifer, Yvonne [1 ]
Schlatterer, Kathrin [2 ]
Engelmann, Elisabeth [3 ]
Schiller, Reinhold A. [4 ]
Frangenberg, Hans Reiner [5 ]
Stiewe, Doris [6 ]
Holfelder, Martin [7 ]
Witte, Wolfgang [1 ]
Nordmann, Patrice [8 ]
Poirel, Laurent [8 ]
机构：
[1] Robert Koch Inst, Wernigerode, Germany
[2] Univ Greifswald, Dept Clin Chem & Lab Med, Greifswald, Germany
[3] Sankt Gertrauden Hosp, Cent Lab, Berlin, Germany
[4] Charite, Inst Microbiol & Hyg, Berlin, Germany
[5] Evangel Krankenhaus, Inst Lab Med & Clin Microbiol, Oberhausen, Germany
[6] Med Lab Wahl, Ludenscheid, Germany
[7] Limbach Lab, Heidelberg, Germany
[8] Hop Bicetre, Dept Microbiol, Le Kremlin De Bicetre, France
来源：
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2012年 / 56卷 / 04期
关键词：
BETA-LACTAMASE; ESCHERICHIA-COLI; RESISTANCE; PLASMID; SPREAD;
D O I：
10.1128/AAC.05315-11
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
Nine carbapenem-resistant Enterobacteriaceae isolates collected from eight patients in five German hospitals were investigated. Six isolates produced the OXA-48 carbapenemase, and three isolates produced OXA-162, which is a point mutant form of OXA-48. Both carbapenemase genes were located on IncL/M-type conjugative plasmids. Insertion sequence IS1999 (truncated or not by IS1R) was located upstream of the bla(OXA-48) and bla(OXA-162) genes in all of the isolates. Pulsed-field gel electrophoresis typing indicated the clonal transmission of an OXA-48-producing Klebsiella pneumoniae strain in two hospitals.
引用
收藏
页码：2125 / 2128
页数：4
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