Solid-phase, multicomponent reactions of methyleneaziridines: Synthesis of 1,3-disubstituted propanones

被引：35
|
作者：
Margathe, JF
Shipman, M
Smith, SC
机构：
[1] Univ Warwick, Dept Chem, Coventry CV4 7AL, W Midlands, England
[2] Syngenta, Jealotts Hill Int Res Ctr, Bracknell RG42 6EY, Berks, England
来源：
ORGANIC LETTERS | 2005年 / 7卷 / 22期
关键词：
D O I：
10.1021/ol051953a
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
[GRAPHICS] Polymer-supported methyleneaziridines undergo ring opening by Grignard reagents under copper catalysis to yield metalloenamines which are alkylated in situ to yield ketimines. Filtration and washing of these Merrifield resin-bound intermediates prior to hydrolysis provides the corresponding 1,3-disubstituted propanones in a high state of purity without recourse to column chromatography.
引用
收藏
页码：4987 / 4990
页数：4
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