Successful Reversal of Hyperalgesia/Myoclonus Complex with Low-Dose Ketamine Infusion

被引：13
|
作者：
Forero, Mauricio
Chan, Philip S. L. [1 ]
Restrepo-Garces, Carlos E. [2 ,3 ]
机构：
[1] McMaster Univ, Dept Anesthesia, Chron Pain Clin, Hamilton, ON, Canada
[2] Hosp Pablo Tobon Uribe, Clin Las Amer, Pain Clin, Dept Surg Anesthesia & Intervent Radiol, Medellin, Colombia
[3] Univ Toronto, Sunnybrook Hlth Sci Ctr, Dept Anesthesia, Toronto, ON M5S 1A1, Canada
来源：
PAIN PRACTICE | 2012年 / 12卷 / 02期
关键词：
opioid tolerance; opioid-induced hyperalgesia; ketamine; intrathecal analgesia; OPIOID-INDUCED HYPERALGESIA; MORPHINE; PAIN; ACTIVATION; MECHANISMS; MYOCLONUS; DELIVERY; THERAPY;
D O I：
10.1111/j.1533-2500.2011.00475.x
中图分类号：
R614 [麻醉学];
学科分类号：
100217 ;
摘要：
We report the successful use of low-dose ketamine infusion for treating a severe episode of painful myoclonus in the lower extremities, associated with opioid-induced hyperalgesia (OIH), in a patient who was receiving long-term, high dose intrathecal hydromorphone therapy. A low-dose ketamine infusion immediately relieved the painful myoclonus. It also enabled a reduction in the intrathecal opioid dosage leading to a resolution of the acute symptoms attributed to OIH.
引用
收藏
页码：154 / 158
页数：5
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