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- [1] Structure-based design of aliskiren, a novel orally effective renin inhibitorBIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2003, 308 (04) : 698 - 705Wood, JMMaibaum, JRahuel, JGrütter, MGCohen, NCRasetti, VRüger, HGöschke, RStutz, SFuhrer, WSchilling, WRigollier, PYamaguchi, YCumin, FBaum, HPSchnell, CRHerold, PMah, RJensen, CO'Brien, EStanton, ABedigian, MP
- [2] Orally efficacious renin inhibitors: New perspectives in a challenging field.ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2004, 228 : U935 - U935Maibaum, J
- [3] Discovery of novel orally bioavailable renin inhibitors by structure based drug designABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2006, 231Edmunds, Jeremy J.Belliotti, ThomasBryant, JohnCai, CuimanCheng, Xue MinCiske, Fred L.Cody, Wayne L.Collard, WendyDowning, Dennis M.Erasga, NoeFerreira, SuzieHall, EricHolsworth, Daniel D.Jalaie, MehranKasani, AparnaKaufman, MichaelLee, ChitaseLi, TingshengMaiti, SamarendraMcConnell, PatrickMennen, KenOstroski, RobertPowell, Noel A.Quinn, John, IIIRahim, MohammadRyan, MichaelStier, Michael A.Subedi, RajandraVan Huis, ChadZhang, Erli
- [4] Design and synthesis of novel potent, non-peptide and orally active renin inhibitorsMEDICINAL CHEMISTRY: TODAY AND TOMORROW, 1997, : 155 - 162Maibaum, JRasetti, VRueger, HCohen, NCGoschke, RMah, RRahuel, JGrutter, MCumin, FWood, JM
- [5] Suppression of the renin system by the novel orally effective direct renin inhibitor aliskiren: A pooled analysis of 1612 patients with hypertensionCIRCULATION, 2006, 114 (18) : 773 - 773Gradman, Alan H.Flack, John M.Arora, VipinZhang, JackAnderson, David R.Keefe, Deborah L.Satlin, AndrewPrescott, Margaret F.
- [6] DESIGN AND SYNTHESIS OF NOVEL POTENT, NON-PEPTIDE AND ORALLY ACTIVE RENIN INHIBITORS.ACTA CRYSTALLOGRAPHICA A-FOUNDATION AND ADVANCES, 1996, 52 : C583 - C583Grutter, M.Maibaum, J.Rasetti, V.Rueger, H.Goschke, R.Mah, R.Cohen, N. C.Rahuel, J.Cumin, F.Wood, J.
- [7] Design and optimization of renin inhibitors: Orally bioavailable alkyl aminesABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2009, 237Tice, Colin M.Xu, ZhenrongYuan, JingSimpson, Robert D.Cacatian, Salvacion T.Flaherty, Patrick T.Zhao, WeiGuo, JoanIshchenko, Alexey V.Singh, Suresh B.Wu, ZhongrenScott, Boyd B.Bukhtiyarov, YuriBerbaum, JenniferMason, JenniferPanemangalore, ReshmaCappiello, Maria GraziaHarrison, Richard K.McGeehan, GerardDillard, Lawrence W.Baldwin, John J.Claremon, David A.
- [8] Design and optimization of renin inhibitors: Orally bioavailable alkyl aminesBIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2009, 19 (13) : 3541 - 3545Tice, Colin M.Xu, ZhenrongYuan, JingSimpson, Robert D.Cacatian, Salvacion T.Flaherty, Patrick T.Zhao, WeiGuo, JoanIshchenko, AlexeySingh, Suresh B.Wu, ZhongrenScott, Boyd B.Bukhtiyarov, YuriBerbaum, JenniferMason, JenniferPanemangalore, ReshmaCappiello, Maria GraziaMueller, DominikHarrison, Richard K.McGeehan, Gerard M.Dillard, Lawrence W.Baldwin, John J.Claremon, David A.
- [9] Iminopyrimidinones: A novel pharmacophore for the development of orally active renin inhibitorsBIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2015, 25 (07) : 1592 - 1596McKittrick, Brian A.Caldwell, John P.Bara, ThomasBoykow, GeorgeChintala, MadhuClader, JohnCzarniecki, MichaelCourneya, BrandyDuffy, RuthFleming, LindaGiessert, RachelGreenlee, William J.Heap, CharlesHong, LiwuHuang, YingIserloh, UlrichJosien, HubertKhan, TanweerKorfmacher, WalterLiang, XianMazzola, RobertMitra, SoumyaMoore, KristinaOrth, PeterRajagopalan, MuraliRoy, SudiptaSakwa, SamuelStrickland, CoreyVaccaro, HenryVoigt, JohannesWang, HongwuWong, JesseZhang, RuminZych, Andrew
- [10] Discovery of novel, conformationally restricted, and orally efficacious DGAT1 inhibitorsABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2013, 245Li, KexueFox, BrianZhang, JianIio, KiyoseiSuzuki, MasahiroSoichiro, ItoOzeki, HidekazuKobayashi, AkioMa, JiHao, AlanLabelle, MarcMcMinn, DustinSmith, MarieSagawa, ShoichiFurukawa, NoboruInaba, TakashiMatsushita, MutsuyoshiMatsui, TakuyaOgawa, NobuyaOkuma, ChihiroSugimoto, KazuyukiTanaka, MasahiroYoshida, AtsuhitoIshii, YukihitoTomimoto, DaisukeJackson, SimonChoi, RebekahShan, BeiSrivastava, AjitKayser, Frank