Antimycobacterial and antifungal activities of Melaleuca alternifolia oil nanoparticles

被引：0

作者：

de Souza, M. Ebling ^{[1
,2
]}

Soares Lopes, L. Quintana ^{[1
,2
]}

Vaucher, R. de Almeida ^{[1
]}

Mario, D. Nunes ^{[3
]}

Alves, S. Hartz ^{[3
]}

Agertt, V. Albertina ^{[4
]}

Bianchini, B. Vendruscolo ^{[4
]}

Felicidade, S. Iensen ^{[2
]}

Anrako de Campus, M. Matiko ^{[4
]}

Boligon, A. Augusti ^{[5
]}

Athayde, M. Linde ^{[5
]}

Santos, C. Genro ^{[2
]}

Baffin, R. Platchek ^{[2
]}

Gomes, P. ^{[2
]}

Vianna Santos, R. Christ ^{[1
,2
]}

机构：

[1] Ctr Univ Franciscano, Programa Posgrad Nanociencias, Lab Pesquisa Microbiol, BR-97010032 Santa Maria, RS, Brazil

[2] Ctr Univ Franciscano, Programa Posgrad Nanociencias, Lab Nanotecnol, BR-97010032 Santa Maria, RS, Brazil

[3] Univ Fed Santa Maria, Dept Microbiol & Parasitol, Lab Pesquisas Micol, Santa Maria, RS, Brazil

[4] Univ Fed Santa Maria, Dept Analises Clin Toxicol, Lab Micobacteriol, Santa Maria, RS, Brazil

[5] Univ Fed Santa Maria, Dept Farm Ind, Lab Fitoquim, Santa Maria, RS, Brazil

来源：

JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY | 2014年 / 24卷 / 05期

关键词：

Tea tree oil; Nanotechnology; Antimicrobial activity; TEA TREE OIL;

D O I：

暂无

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Tea tree oil (TTO), derived from M. alternifolia, has been widely used as an antimicrobial agent. Nanoparticles show completely new or improved properties based on specific characteristics such as particle size, distribution, and morphology. It can also enhance the stability of the oil, preventing or reducing the volatilization. In this way, the antimicrobial activities of TTO nanoparticles were evaluated against six Mycobacterium and eleven fungal species. TTO and TTO nanoparticles were active against both bacteria and fungi with MICs ranged from 0.002 to 2.5 %. The results showed that TTO nanoencapsulation maintains TTO activity, indicating that the use of nanotechnology may represent an alternative for the treatment of mycobacterial and fungal diseases.

引用

页码：559 / 560

页数：2

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