Hypercholesterolemia and obesity in adult patients with hypopituitarism: A report of a nation-wide survey in Japan

被引:10
|
作者
Murakami, Y [1 ]
Kato, Y [1 ]
机构
[1] Shimane Med Univ, Sch Med, Dept Endocrinol Matabolism & Hematol Oncol, Izumo, Shimane 6938501, Japan
关键词
hypopituitarism; hypercholesterolemia; obesity;
D O I
10.1507/endocrj.50.759
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Dyslipidemia and obesity are common in adult patients with hypopituitarism. Possible contributions of age, sex and hormone deficiencies to hypercholesterolemia and obesity in adult hypopituitary patients were analyzed in 1, 272 Japanese cases based on a database of a national survey on adult hypopituitarism. In patients on routine hormone replacement therapy, 30.5% of male and 40.7% of female subjects were considered hypercholesterolemic. In univariate analysis, hypercholesterolemia was more prevalent in female, aged, untreated Gn-deficient and TSH-deficient groups. In multivariate analysis, sex of female, age older than 40 yr and TSH deficiency were the independent contributing factors to hypercholesterolemia. Obesity (body mass index (BMI) greater than or equal to25 kg/m(2)) was more prevalent in male, TSH-deficient and ADH-deficient groups. Severe obesity (BMI greater than or equal to30) was observed in high prevalence in the youngest group. These findings suggest that hypercholesterolemia and obesity were prevalent in different age and gender groups in Japanese adult patients with hypopituitarism. Insufficient replacement of thyroid hormone and possibly gonadotropin deficiency might contribute to hypercholesterolemia. In contrast, hypothalamic dysfunction as well as hormone deficiencies might play roles in obesity in these patients.
引用
收藏
页码:759 / 765
页数:7
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