Childhood Socioeconomic Circumstances, Inflammation, and Hemostasis Among Midlife Women: Study of Women's Health Across the Nation

被引:13
|
作者
Matthews, Karen A. [1 ,2 ,3 ]
Chang, Yuefang [4 ]
Bromberger, Joyce T. [3 ]
Karvonen-Gutierrez, Carrie A. [5 ]
Kravitz, Howard M. [6 ,7 ]
Thurston, Rebecca C. [1 ,2 ,3 ]
Montez, Jennifer Karas [8 ]
机构
[1] Univ Pittsburgh, Dept Psychiat, 3811 Ohara St, Pittsburgh, PA 15213 USA
[2] Univ Pittsburgh, Dept Psychol, Pittsburgh, PA 15213 USA
[3] Univ Pittsburgh, Dept Epidemiol, Pittsburgh, PA 15213 USA
[4] Univ Pittsburgh, Dept Neurol Surg, Pittsburgh, PA 15213 USA
[5] Univ Michigan, Sch Publ Hlth, Dept Epidemiol, Ann Arbor, MI 48109 USA
[6] Rush Univ, Med Ctr, Dept Psychiat, Chicago, IL 60612 USA
[7] Rush Univ, Med Ctr, Dept Prevent Med, Chicago, IL 60612 USA
[8] Syracuse Univ, Dept Sociol, Syracuse, NY USA
来源
PSYCHOSOMATIC MEDICINE | 2016年 / 78卷 / 03期
基金
美国国家卫生研究院;
关键词
Socioeconomic status; childhood; inflammation; hemostasis; race; women; C-REACTIVE PROTEIN; CARDIOVASCULAR-DISEASE; YOUNG-ADULTS; RISK-FACTORS; SOCIAL-CLASS; MARKERS; LIFE; FIBRINOGEN; POSITION; RECALL;
D O I
10.1097/PSY.0000000000000283
中图分类号
R749 [精神病学];
学科分类号
100205 ;
摘要
Background: Childhood socioeconomic status (SES) is related to risk for cardiovascular disease in adulthood, perhaps, in part, due to associations with inflammatory and hemostasis processes. We tested the hypotheses that childhood SES is related to C-reactive protein (CRP), fibrinogen, factor VIIc, and plasminogen activator inhibitor-1 (PAI-1) in midlife women and that the associations are mediated by adult SES and/or adult body mass index (BMI). Methods: Using data from the prospective Study of Women's Health Across the Nation, we classified 1067 black and whitewomen into 3multidimensional childhood SES groups based on latent class analysis. Biological measures were assessed across 7 years along with covariates and mediators and analyzed by mixed regression models, followed by tests for mediation. Results: Compared with women raised in high SES families, those from the lowest SES families had higher levels of CRP (b [standard error] = 0.37 [0.11]), PAI-1 (b = 0.23 [0.07]) factor VIIc (b = 0.05 [0.02]), and fibrinogen (b = 11.06 [4.89]), after adjustment for ethnicity, site, age, ratings of health between ages 11 and 18 years, visit, smoking status, menopausal status, stroke or heart attack, medications, and hormone use. Introduction of adult SES and BMI into the models reduced the childhood SES associations to nonsignificance for all four measures. Indirect mediation was apparent for adult education and BMI for CRP, and BMI for PAI-1. Conclusions: Women raised in lower SES families had elevated markers of inflammation and hemostasis, in part, due to elevated BMI and education in adulthood.
引用
收藏
页码:311 / 318
页数:8
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