Unemployment is a pervasive and stubborn feature of contemporary social and economic life. This review article focuses on the meaning and experience of contemporary white-collar unemployment in the United States. After explaining the empirical and theoretical rationales for the focus on white-collar workers, this review delves into three aspects of white-collar unemployment: who loses jobs; what unemployment means for one's sense of self, marital relationships, parent-child relationships; and how the process of job-searching and re-employment unfold for unemployed white-collar workers in the US. Throughout, I take an intersectional approach, identifying how sensitivity to structural location in the labor market and the family can augment our sociological understandings of these important issues. I close by suggesting directions for future research.