Improving the throughput of batch photochemical reactions using flow: Dual photoredox and nickel catalysis in flow for C(sp2)-C(sp3) cross-coupling

被引：28
|
作者：
Abdiaj, Irini [1 ]
Alcazar, Jesus [1 ]
机构：
[1] Janssen Cilag SA, Janssen Res & Dev, C Jarama 75, Toledo 45007, Spain
来源：
BIOORGANIC & MEDICINAL CHEMISTRY | 2017年 / 25卷 / 23期
关键词：
Photoredox; Dual catalysis; Flow chemistry; C(sp(2))-C(sp(3)) cross-coupling; Medicinal chemistry; MICROWAVE INSTRUMENTS; MEDICINAL CHEMISTS; LIGHT; REACTORS; REPRODUCIBILITY; PERSPECTIVE; SCALE;
D O I：
10.1016/j.bmc.2016.12.041
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
We report herein the transfer of dual photoredox and nickel catalysis for C(sp(2))-C(sp(3)) cross coupling form batch to flow. This new procedure clearly improves the scalability of the previous batch reaction by the reactor's size and operating time reduction, and allows the preparation of interesting compounds for drug discovery in multigram amounts. (C) 2017 The Authors. Published by Elsevier Ltd.
引用
收藏
页码：6190 / 6196
页数：7
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