Diagnostic Importance of Hyphae on Heart Valve Tissue in Histoplasma Endocarditis and Treatment With Isavuconazole

被引：10

作者：

Wiley, Zanthia ^{[1
]}

Woodworth, Michael H. ^{[1
]}

Jacob, Jesse T. ^{[1
]}

Lockhart, Shawn R. ^{[2
]}

Rouphael, Nadine G. ^{[1
]}

Gullett, Jonathan C. ^{[3
]}

Guarner, Jeannette ^{[4
]}

Workowski, Kimberly ^{[1
]}

机构：

[1] Emory Univ, Sch Med, Dept Med, Div Infect Dis, Atlanta, GA USA

[2] Ctr Dis Control & Prevent, Mycot Dis Branch, Fungal Reference Lab, Atlanta, GA USA

[3] Southern Calif Permanente Med Grp, Reg Reference Labs, Greater Los Angeles Area, Microbiol, Los Angeles, CA USA

[4] Emory Univ, Sch Med, Pathol & Lab Med, Atlanta, GA USA

来源：

OPEN FORUM INFECTIOUS DISEASES | 2017年 / 4卷 / 04期

基金：

美国国家卫生研究院;

关键词：

fungal endocarditis; Histoplasma capsulatum; histoplasmosis; hyphae; isavuconazole; INFECTIONS; CAPSULATUM;

D O I：

10.1093/ofid/ofx241

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

A patient who never resided in an endemic area for dimorphic fungi was diagnosed with Histoplasma capsulatum endocarditis. His diagnosis was suggested by yeast and hyphae on cardiac valve tissue pathology. Isavuconazole was an optimal therapeutic option due to renal dysfunction and anticoagulation with warfarin for mechanical valve replacement.

引用

页数：2

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