Six cases of daptomycin-non-susceptible Staphylococcus aureus bacteraemia in Singapore

被引：14

作者：

Hsu, Li-Yang ^{[1
]}

Leong, Micky ^{[1
]}

Balm, Michelle ^{[1
]}

Chan, Douglas S. ^{[1
]}

Huggan, Paul ^{[1
]}

Tan, Thean-Yen ^{[2
]}

Koh, Tse-Hsien ^{[3
]}

Hon, Pei-Yun ^{[1
]}

Ng, Mary M. ^{[1
]}

机构：

[1] Natl Univ Hlth Syst, Singapore, Singapore

[2] Changi Gen Hosp, Singapore, Singapore

[3] Singapore Gen Hosp, Singapore 0316, Singapore

来源：

JOURNAL OF MEDICAL MICROBIOLOGY | 2010年 / 59卷 / 12期

关键词：

METHICILLIN-RESISTANT; VANCOMYCIN;

D O I：

10.1099/jmm.0.022533-0

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

We report what we believe to be the first six cases of daptomycin-non-susceptible Staphylococcus aureus infections from Singapore These strains were rapidly isolated after bacteraemic patients were switched to daptomycin following initial prolonged unsuccessful therapy with vancomycin, despite confirmation of daptomycin susceptibility just prior to initiating daptomycin therapy The majority of post-vancomycin therapy strains exhibited marked thickening of their cell walls on electron microscopic examination In patients with persistent S aureus bacteraemia, therapeutic failure with daptomycin may occur if used as salvage therapy following vancomycin failure, notwithstanding initial susceptibility testing results

引用

页码：1509 / 1513

页数：5

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