Carba-nucleosides as potent antagonists of the adenosine 5′-diphosphate (ADP) purinergic receptor (P2Y12) on human platelets

被引：9
|
作者：
Ye, Hong [1 ]
Chen, Cailin [1 ]
Zhang, Han-Cheng [1 ]
Haertlein, Barbara [1 ]
Parry, Tom J. [1 ]
Damiano, Bruce P. [1 ]
Maryanoff, Bruce E. [1 ]
机构：
[1] Johnson & Johnson Pharmaceut Res & Dev, Spring House, PA 19477 USA
来源：
CHEMMEDCHEM | 2008年 / 3卷 / 05期
关键词：
ADP receptor; antagonist; nucleosides; P2Y(12) receptor; platelet; purinergic;
D O I：
10.1002/cmdc.200700310
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Antagonizing a key platelet purinergic receptor. The wide clinical use of clopidogrel has highlighted the importance of platelet ADP receptor (P2Y 12) antagonists for preventing adverse cardiovascular events. We synthesized a series of novel carba-nucleosides and examined their usefulness as P2Y12 antagonists. Some tetrazole derivatives were high-affinity receptor antagonists and potent inhibitors of human platelet aggregation. (Chemical Equation Presented) © 2008 Wiley-VCH Verlag GmbH & Co. KGaA.
引用
收藏
页码：732 / 736
页数：5
相关论文
共 50 条
  • [1] Novel P2Y12 adenosine diphosphate receptor antagonists for inhibition of platelet aggregation (I):: In vitro effects on platelets
    Bryant, Judi
    Post, Joseph M.
    Alexander, Serene
    Wang, Yi-Xin
    Kent, Lorraine
    Schirm, Sabine
    Tseng, Jih-Lie
    Subramanyam, Babu
    Buckman, Brad
    Islam, Imadul
    Yuan, Shendong
    Sullivan, Mark E.
    Snider, Mike
    Morser, John
    THROMBOSIS RESEARCH, 2008, 122 (04) : 523 - 532
  • [2] Clopidogrel and ticlopidine:: P2Y12 adenosine diphosphate-receptor antagonists for the prevention of atherothrombosis
    Savi, P
    Herbert, JM
    SEMINARS IN THROMBOSIS AND HEMOSTASIS, 2005, 31 (02): : 174 - 183
  • [3] Effects of P2Y1 and P2Y12 receptor antagonists on ADP-induced shape change of equine platelets:: comparison with human platelets
    Mateos-Trigos, G
    Evans, RJ
    Heath, MF
    PLATELETS, 2002, 13 (5-6) : 285 - 292
  • [4] Formation of coated platelets is regulated by the dense granule secretion of adenosine 5′diphosphate acting via the P2Y12 receptor
    Kotova, Y. N.
    Ataullakhanov, F. I.
    Panteleev, M. A.
    JOURNAL OF THROMBOSIS AND HAEMOSTASIS, 2008, 6 (09) : 1603 - 1605
  • [5] Molecular modeling of purinergic receptor P2Y12 and interaction with its antagonists
    Zhan, Chenyang
    Yang, Jie
    Dong, Xian-Chi
    Wang, Yue-Lan
    JOURNAL OF MOLECULAR GRAPHICS & MODELLING, 2007, 26 (01): : 20 - 31
  • [6] Novel molecular association of ADP purinergic receptor, P2Y12 with tetraspanin superfamily member, CD151 in human platelets
    Moheimani, F.
    Ashman, L. K.
    Wright, M. D.
    Jackson, D. E.
    JOURNAL OF THROMBOSIS AND HAEMOSTASIS, 2011, 9 : 776 - 777
  • [7] A complementary role for tetraspanin superfamily member CD151 and ADP purinergic P2Y12 receptor in platelets
    Makkawi, Mohammed
    Moheimani, Fatemeh
    Alserihi, Raed
    Howells, David
    Wright, Mark
    Ashman, Leonie
    Jackson, Denise E.
    THROMBOSIS AND HAEMOSTASIS, 2015, 114 (05) : 1004 - 1019
  • [8] A complementary role for tetraspanin superfamily member TSSC6 and ADP purinergic P2Y12 receptor in platelets
    Makkawi, Mohammed
    Howells, David
    Wright, Mark D.
    Jackson, Denise E.
    THROMBOSIS RESEARCH, 2018, 161 : 12 - 21
  • [9] Effects of a P2Y12 receptor antagonist on the response of equine platelets to ADP.: Comparison with human platelets
    Mateos-Trigos, G
    Evans, RJ
    Heath, MF
    RESEARCH IN VETERINARY SCIENCE, 2002, 73 (02) : 171 - 175
  • [10] Impact of genetic polymorphisms in the clinical response of oral inhibitors of the platelet P2Y12 adenosine diphosphate (ADP) receptor
    Simon, T.
    ANNALES DE CARDIOLOGIE ET D ANGEIOLOGIE, 2010, 59 : S90 - S94
12345