Enantioselective catalytic carbonyl-ene cyclization reactions

被引：63
|
作者：
Grachan, Melissa L. [1 ]
Tudge, Matthew T. [1 ]
Jacobsen, Eric. N. [1 ]
机构：
[1] Harvard Univ, Dept Chem & Chem Biol, Cambridge, MA 02138 USA
来源：
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2008年 / 47卷 / 08期
关键词：
aldehydes; asymmetric catalysis; chromium; cyclization; ene reaction;
D O I：
10.1002/anie.200704439
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
(Chemical Equation Presented) Intramolecular ene reactions of simple alkenyl aldehydes are catalyzed by a chiral (Schiff base)CrIII complex with high enantio-and diastereoselectivity, affording densely functionalized heterocyclic or carbocyclic products (see scheme for example). Desymmetrizations of alkenyl dialdehydes and bis(alkenyl) aldehydes are also achieved. © 2008 Wiley-VCH Verlag GmbH & Co. KGaA.
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收藏
页码：1469 / 1472
页数：4
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