ERK1/2 Inhibition Overcomes Resistance in Acute Myeloid Leukemia (AML) and Alters Mitochondrial Dynamics

被引:3
|
作者
Sharma, Priyanka [1 ,2 ]
Piya, Sujan [1 ,2 ]
Ma, Huaxian [1 ,2 ]
Baran, Natalia [3 ]
Zal, Malgorzata Anna [3 ]
Hindley, Christopher J. [4 ]
Dao, Kim-Hien [5 ]
Sims, Martin
Zal, Tomasz [3 ]
Ruvolo, Vivian [1 ,2 ]
Andreeff, Michael [3 ]
Borthakur, Gautam [3 ]
机构
[1] MD Anderson Canc Ctr, Dept Leukemia, Houston, TX USA
[2] MD Anderson Canc Ctr, Sect Mol Hematol & Therapy, Houston, TX USA
[3] Univ Texas MD Anderson Canc Ctr, Dept Leukemia, Houston, TX 77030 USA
[4] Astex Pharmaceut, Cambridge, England
[5] Astex Pharmaceut Inc, Pleasanton, CA USA
关键词
D O I
10.1182/blood-2021-151579
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
3338
引用
收藏
页数:5
相关论文
共 50 条
  • [1] ERK1/2 inhibition overcomes resistance to venetoclax in AML by altering mitochondrial metabolism
    Sharma, Priyanka
    Ostermann, Lauren
    Piya, Sujan
    Baran, Natalia
    Tyagi, Anudishi
    Hindley, Christopher
    Dao, Kim-Hien
    Sims, Martin
    Battula, V. Lokesh
    Andreeff, Michael
    Borthakur, Gautam
    CANCER RESEARCH, 2023, 83 (07)
  • [2] ERK1/2 Inhibition Overcomes Resistance to Venetoclax in AML By Inhibiting Drp1 Dependent Mitochondrial Fission
    Sharma, Priyanka
    Ostermann, Lauren B.
    Piya, Sujan
    Ke, Baozhen
    Baran, Natalia
    Tyagi, Anudishi
    Muftuoglu, Muharrem
    Basyal, Mahesh
    Zhang, Qi
    Munck, Joanne
    Dao, Kim-Hien
    Sims, Martin
    Carter, Bing Z.
    Battula, Venkata Lokesh
    Andreeff, Michael
    Borthakur, Gautam
    BLOOD, 2023, 142
  • [3] ERK1/2 Inhibition Overcomes Resistance to Venetoclax in AML By Altering Drp1-Dependent Mitochondrial Fission and Metabolism
    Sharma, Priyanka
    Piya, Sujan
    Baran, Natalia
    Zal, Anna
    Hindley, Christopher J.
    Dao, Kim-Hien
    Sims, Martin
    Zal, Tomasz
    Ruvolo, Vivian
    Andreeff, Michael
    Borthakur, Gautam
    BLOOD, 2022, 140 : 8789 - 8790
  • [4] Inhibition of ERK1/2 Reverses Venetoclax-Induced Autophagy to Overcome Resistance in Acute Myeloid Leukemia
    Sharma, Priyanka
    Piya, Sujan
    Baran, Natalia
    Muftuoglu, Muharrem
    Basyal, Mahesh
    Ruvolo, Vivian
    Hindley, Christopher J.
    Dao, Kim-Hien
    Sims, Martin
    Andreeff, Michael
    Borthakur, Gautam
    BLOOD, 2022, 140 : 3093 - 3094
  • [5] MUC1 Inhibition Overcomes Chemotherapy Resistance in Acute Myeloid Leukemia
    Nahas, Myrna Rita
    Stroopinsky, Dina
    Rajabi, Hasan
    Tagde, Ashujit
    Pyzer, Athalia Rachel
    Jain, Salvia
    Coll, Maxwell Douglas
    Bar-Natan, Michal
    Karp, Rebecca
    Luptakova, Katarina
    Palmer, Kristen Anna
    Somaiya, Poorvi
    Arnason, Jon
    McMasters, Malgorzata
    Joyce, Robin
    Levine, James D.
    Kufe, Donald
    Avigan, David
    Rosenblatt, Jacalyn
    BLOOD, 2015, 126 (23)
  • [6] Inhibition of Mitochondrial Translation As a Therapeutic Strategy for Acute Myeloid Leukemia (AML)
    Skrtic, Marko
    Sriskanthadevan, Shrivani
    Livak, Bozhena
    Gebbia, Marinella
    Wang, Xiaoming
    Wang, Zezhou
    Hurren, Rose
    Jitkova, Yulia
    Gronda, Marcela
    Maclean, Neil
    Lai, Courteney
    Eberhard, Yanina
    Bartoszko, Justyna
    Spagnuolo, Paul A.
    Rutledge, Angela
    Datti, Alessandro
    Ketela, Troy
    Moffat, Jason
    Robinson, Brian H.
    Cameron, Jessie M.
    Wrana, Jeff L.
    Eaves, Connie J.
    Minden, Mark D.
    Wang, Jean C. Y.
    Dick, John E.
    Humphries, R. Keith
    Nislow, Corey
    Giaever, Guri
    Schimmer, Aaron D.
    BLOOD, 2011, 118 (21) : 106 - 107
  • [7] Targeting Mitochondrial Translation Overcomes Venetoclax Resistance in Acute Myeloid Leukemia (AML) through Activation of the Integrated Stress Response
    Sharon, David
    Cathelin, Severine
    Subedi, Amit
    Williams, Ryan
    Benicio, Mariana
    Ketela, Troy
    Chan, Steven M.
    BLOOD, 2017, 130
  • [8] Continous exposure to methothrexate (MTX) overcomes resistance in childhood acute myeloid leukemia (AML) in vitro
    Rots, MG
    Zwaan, CM
    Pieters, R
    Kaspers, GJL
    Noordhuis, P
    van Zantwijk, CH
    Creutzig, U
    Peters, GJ
    Veerman, AJP
    Jansen, G
    PEDIATRIC RESEARCH, 1999, 45 (05) : 775 - 775
  • [9] Continuous Exposure to Methotrexate (MTX) Overcomes Resistance in Childhood Acute Myeloid Leukemia (AML) in Vitro
    M G Rots
    Ch M Zwaan
    R Pieters
    G J L Kaspers
    P Noordhuis
    C H Van Zantwijk
    U Creutzig
    G J Peters
    A J P Veerman
    G Jansen
    Pediatric Research, 1999, 45 : 775 - 775
  • [10] BCL-2 inhibition in Acute Myeloid Leukemia (AML)
    Konopleva, Marina
    Daver, Naval
    DiNardo, Courtney
    CLINICAL LYMPHOMA MYELOMA & LEUKEMIA, 2018, 18 : S9 - S10