Electronic Microarrays in DNA Computing

被引：0

作者：

Akin, H. E. ^{[2
]}

Karabay, D. A. O. ^{[3
]}

Kyle, J. R. ^{[2
]}

Mills, A. P., Jr. ^{[3
]}

Ozkan, C. S. ^{[1
]}

Ozkan, M. ^{[2
]}

机构：

[1] Univ Calif Riverside, Dept Mech Engn, Riverside, CA 92521 USA

[2] Univ Calif Riverside, Dept Elect Engn, Riverside, CA 92521 USA

[3] Univ Calif Riverside, Dept Phys & Astron, Riverside, CA 92521 USA

来源：

JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY | 2011年 / 11卷 / 03期

基金：

美国国家科学基金会;

关键词：

DNA Computing; Electronic Microarrays; Microelectronics; MOLECULAR COMPUTATION; MICROELECTRONIC CHIP; HYBRIDIZATION; MUTATIONS; LIGATION; MISMATCH; MACHINE; DESIGN;

D O I：

10.1166/jnn.2011.3422

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

DNA Computing is a rapidly-developing interdisciplinary area which could benefit from more experimental results to solve practical problems with the current biological tools. In this study, we have integrated microelectronics and molecular biology techniques for the storage of information and basic arithmetic operations via DNA. Using 16 different complementary sequences of DNA, we stored 4 bits of information on an electronic microarray and read the data via the fluorescent signal strength coming from the microarray pads. We also showed the possibility of addition and subtraction of quantities of fluorescently tagged DNA determined via their fluorescent signal strength. We conclude that the hybrid technology we employed, based on a matured Si-CMOS platform, has the potential to strengthen the pursuit of DNA computation as well as finding its own niche applications.

引用

页码：1859 / 1865

页数：7

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