Striatal dopamine transporter in Parkinson's disease studied with [I-123]beta-CIT-FP SPET

被引：0
|
作者：
Kuikka, JT
Rinne, JO
Bergstrom, KA
Kilpelainen, H
Lehtovirta, M
Rinne, UK
机构：
来源：
RADIOACTIVE ISOTOPES IN CLINICAL MEDICINE AND RESEARCH | 1997年
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D O I：
暂无
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Six healthy controls and 13 patients with Parkinson's disease in different disability stages were studied with high resolution SPET using [I-123]beta-CIT-FP. The caudatus-to-cerebellum and putamen-to-cerebellum ratios were calculated at 3.5 hours after injection. Patients had the significantly lower ratio than that of the controls in the putamen (3.0 +/- 1.0 vs. 4.7 +/- 0.4) and in the caudatus (3.5 +/- 1.1 vs. 4.9 +/- 0.5), respectively. There was a significant negative correlation between the ratio and the Hoehn and Yahr stage in the putamen (r = -0.74) and in the caudatus(r = -0.80). Reduced striatal uptake demonstrates the loss of presynaptic nerve endings in the striatum of the patients with Parkinson's disease.
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页码：131 / 136
页数：6
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