Conservative treatment in epithelial ovarian cancer:: results of a multicentre study of the GCCLCC (Groupe des Chirurgiens de Centre de Lutte Contre le Cancer) and SFOG (Societe Francaise d'Oncologie Gynecologique)

被引:107
|
作者
Morice, P
Leblanc, E
Rey, A
Baron, M
Querleu, D
Blanchot, J
Duvillard, P
Lhommé, C
Castaigne, D
Classe, JM
Bonnier, P
机构
[1] Inst Gustave Roussy, Serv Chirurg, F-94805 Villejuif, France
[2] Ctr Oscar Lambret, F-59020 Lille, France
[3] Ctr Henri Becquerel, F-76038 Rouen, France
[4] Inst Claudius Regaud, F-31052 Toulouse, France
[5] Ctr Eugene Marquis, F-35042 Rennes, France
[6] Ctr Lutte Canc, Grp Chirurg, Paris, France
关键词
conservative surgery; epithelial ovarian tumour; pregnancy; recurrence; restaging surgery;
D O I
10.1093/humrep/deh777
中图分类号
R71 [妇产科学];
学科分类号
100211 ;
摘要
BACKGROUND: Results of conservative management of epithelial ovarian cancer (EOC) remain controversial in the literature. The aim of this study was to assess the clinical outcomes and fertility following fertility-sparing surgical management of EOC in a retrospective multicentre study. METHODS: A multicentre retrospective study was performed by members of two French groups. Six inclusion criteria were defined: (i) Histological review by the same pathologist; (ii) age <= 40 years; (iii) conservative management; (iv) complete peritoneal staging; (v) delivery of a platinum-based chemotherapy in stage >= IC; and (vi) follow-up >1 year. RESULTS: Thirty-four patients fulfilled the inclusion criteria: 30 had stage IA disease; three had stage IC and one had stage IIA. Eleven patients had recurrence: 10 patients had invasive disease and one had borderline recurrence. Among 10 patients with invasive recurrence, initial stage and grade were: stage IA G1, n=1; stage IA G2, n=4; stage IA G3, n=1; and stage >= IC, n=4. All patients with stage > IA had recurrence. Ten pregnancies were observed in nine patients. CONCLUSION: Conservative surgery for patients with EOC could be considered in young patients with stage IA G1 disease. This procedure should not be performed in patients with FIGO stage > IA.
引用
收藏
页码:1379 / 1385
页数:7
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