The UK Biobank imaging enhancement of 100,000 participants:rationale, data collection, management and future directions

被引：440

作者：

Littlejohns, Thomas J. ^{[1
]}

Holliday, Jo ^{[1
]}

Gibson, Lorna M. ^{[2
,3
]}

Garratt, Steve ^{[4
]}

Oesingmann, Niels ^{[4
]}

Alfaro-Almagro, Fidel ^{[5
]}

Bell, Jimmy D. ^{[6
]}

Boultwood, Chris ^{[4
]}

Collins, Rory ^{[1
]}

Conroy, Megan C. ^{[1
]}

Crabtree, Nicola ^{[7
]}

Doherty, Nicola ^{[4
]}

Frangi, Alejandro F. ^{[8
,9
]}

Harvey, Nicholas C. ^{[10
]}

Leeson, Paul ^{[11
]}

Miller, Karla L. ^{[5
]}

Neubauer, Stefan ^{[11
]}

Petersen, Steffen E. ^{[12
]}

Sellors, Jonathan ^{[1
,4
]}

Sheard, Simon ^{[4
]}

Smith, Stephen M. ^{[5
]}

Sudlow, Cathie L. M. ^{[2
]}

Matthews, Paul M. ^{[13
,14
]}

Allen, Naomi E. ^{[1
]}

机构：

[1] Univ Oxford, Nuffield Dept Populat Hlth, Oxford, England

[2] Univ Edinburgh, Usher Inst Populat Hlth Sci & Informat, Edinburgh, Midlothian, Scotland

[3] New Royal Infirm Edinburgh, Dept Clin Radiol, Edinburgh, Midlothian, Scotland

[4] UK Biobank Coordinating Ctr, Stockport, Lancs, England

[5] Univ Oxford, Ctr Funct MRI Brain, Wellcome Ctr Integrat Neuroimaging, Oxford, England

[6] Univ Westminster, Res Ctr Optimal Hlth, London, England

[7] Birmingham Womens & Childrens NHS Fdn Trust, Birmingham, W Midlands, England

[8] Katholieke Univ Leuven, Dept Cardiovasc Sci & Elect Engn, Leuven, Belgium

[9] Univ Leeds, CISTIB Ctr Computat Imaging & Simulat Technol Bio, Sch Comp & Med, Leeds, W Yorkshire, England

[10] Univ Southampton, MRC Lifecourse Epidemiol Unit, Southampton, Hants, England

[11] Univ Oxford, Radcliffe Dept Med, Oxford, England

[12] Queen Mary Univ Med, William Harvey Res Inst, London, England

[13] Imperial Coll London, Dept Brain Sci, London, England

[14] UK Dementia Res Inst, London, England

来源：

NATURE COMMUNICATIONS | 2020年 / 11卷 / 01期

基金：

英国工程与自然科学研究理事会; 欧盟地平线“2020”; 英国惠康基金; 英国医学研究理事会;

关键词：

MINOR ECG ABNORMALITIES; LEFT-VENTRICULAR MASS; X-RAY ABSORPTIOMETRY; ALL-CAUSE MORTALITY; CARDIOVASCULAR-DISEASE; INDEPENDENT PREDICTOR; MAGNETIC-RESONANCE; ABDOMINAL FAT; BODY-FAT; RISK;

D O I：

10.1038/s41467-020-15948-9

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

UK Biobank is a population-based cohort of half a million participants aged 40-69 years recruited between 2006 and 2010. In 2014, UK Biobank started the world's largest multi-modal imaging study, with the aim of re-inviting 100,000 participants to undergo brain, cardiac and abdominal magnetic resonance imaging, dual-energy X-ray absorptiometry and carotid ultrasound. The combination of large-scale multi-modal imaging with extensive phenotypic and genetic data offers an unprecedented resource for scientists to conduct health-related research. This article provides an in-depth overview of the imaging enhancement, including the data collected, how it is managed and processed, and future directions. Between 2014 and 2023, 100,000 UK Biobank participants are undergoing brain, heart and abdominal MRI, as well as DXA and carotid ultrasound scans. In this review, authors provide a detailed overview of the rationale for the collection of these imaging data, the procedures of data collection and management, and the future directions of the UK biobank imaging enhancement.

引用

页数：12

共 87 条

[1] Image processing and Quality Control for the first 10,000 brain imaging datasets from UK Biobank [J].

Alfaro-Almagro, Fidel ;

Jenkinson, Mark ;

Bangerter, Neal K. ;

Andersson, Jesper L. R. ;

Griffanti, Ludovica ;

Douaud, Gwenaelle ;

Sotiropoulos, Stamatios N. ;

Jbabdi, Saad ;

Hernandez-Fernandez, Moises ;

Vallee, Emmanuel ;

Vidaurre, Diego ;

Webster, Matthew ;

McCarthy, Paul ;

Rorden, Christopher ;

Daducci, Alessandro ;

Alexander, Daniel C. ;

Zhang, Hui ;

Dragonu, Iulius ;

Matthews, Paul M. ;

Miller, Karla L. ;

Smith, Stephen M. .

NEUROIMAGE, 2018, 166 :400-424

[2]

[Anonymous], 1994, World Health Organ Tech Rep Ser, V843, P1

[3] Quantitative CMR population imaging on 20,000 subjects of the UK Biobank imaging study: LV/RV quantification pipeline and its evaluation [J].

Attar, Rahman ;

Pereanez, Marco ;

Gooya, Ali ;

Alba, Xenia ;

Zhang, Le ;

de Vila, Milton Hoz ;

Lee, Aaron M. ;

Aung, Nay ;

Lukaschuk, Elena ;

Sanghvi, Mihir M. ;

Fung, Kenneth ;

Paiva, Jose Miguel ;

Piechnik, Stefan K. ;

Neubauer, Stefan ;

Petersen, Steffen E. ;

Frangi, Alejandro F. .

MEDICAL IMAGE ANALYSIS, 2019, 56 :26-42

[4] Association of Major and Minor ECG Abnormalities With Coronary Heart Disease Events [J].

Auer, Reto ;

Bauer, Douglas C. ;

Marques-Vidal, Pedro ;

Butler, Javed ;

Min, Lauren J. ;

Cornuz, Jacques ;

Satterfield, Suzanne ;

Newman, Anne B. ;

Vittinghoff, Eric ;

Rodondi, Nicolas .

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2012, 307 (14) :1497-1505

[5] Association Between Ambient Air Pollution and Cardiac Morpho-Functional Phenotypes Insights From the UK Biobank Population Imaging Study [J].

Aung, Nay ;

Sanghvi, Mihir M. ;

Zemrak, Filip ;

Lee, Aaron M. ;

Cooper, Jackie A. ;

Paiva, Jose M. ;

Thomson, Ross J. ;

Fung, Kenneth ;

Khanji, Mohammed Y. ;

Lukaschuk, Elena ;

Carapella, Valentina ;

Kim, Young Jin ;

Munroe, Patricia B. ;

Piechnik, Stefan K. ;

Neubauer, Stefan ;

Petersen, Steffen E. .

CIRCULATION, 2018, 138 (20) :2175-2186

[6] Automated cardiovascular magnetic resonance image analysis with fully convolutional networks [J].

Bai, Wenjia ;

Sinclair, Matthew ;

Tarroni, Giacomo ;

Oktay, Ozan ;

Rajchl, Martin ;

Vaillant, Ghislain ;

Lee, Aaron M. ;

Aung, Nay ;

Lukaschuk, Elena ;

Sanghvi, Mihir M. ;

Zemrak, Filip ;

Fung, Kenneth ;

Paiva, Jose Miguel ;

Carapella, Valentina ;

Kim, Young Jin ;

Suzuki, Hideaki ;

Kainz, Bernhard ;

Matthews, Paul M. ;

Petersen, Steffen E. ;

Piechnik, Stefan K. ;

Neubauer, Stefan ;

Glocker, Ben ;

Rueckert, Daniel .

JOURNAL OF CARDIOVASCULAR MAGNETIC RESONANCE, 2018, 20

[7] Whole-Body MR Imaging in the German National Cohort:Rationale, Design, and Technical Background [J].

Bamberg, Fabian ;

Kauczor, Hans-Ulrich ;

Weckbach, Sabine ;

Schlett, Christopher L. ;

Forsting, Michael ;

Ladd, Susanne C. ;

Greiser, Karin Halina ;

Weber, Marc-Andre ;

Schulz-Menger, Jeanette ;

Niendorf, Thoralf ;

Pischon, Tobias ;

Caspers, Svenja ;

Amunts, Katrin ;

Berger, Klaus ;

Buelow, Robin ;

Hosten, Norbert ;

Hegenscheid, Katrin ;

Kroencke, Thomas ;

Linseisen, Jakob ;

Guenther, Matthias ;

Hirsch, Jochen G. ;

Koehn, Alexander ;

Hendel, Thomas ;

Wichmann, Heinz-Erich ;

Schmidt, Boege ;

Joeckel, Karl-Heinz ;

Hoffmann, Wolfgang ;

Kaaks, Rudolf ;

Reiser, Maximilian F. ;

Voelzke, Henry .

RADIOLOGY, 2015, 277 (01) :206-220

[8] Multiparametric magnetic resonance for the non-invasive diagnosis of liver disease [J].

Banerjee, Rajarshi ;

Pavlides, Michael ;

Tunnicliffe, Elizabeth M. ;

Piechnik, Stefan K. ;

Sarania, Nikita ;

Philips, Rachel ;

Collier, Jane D. ;

Booth, Jonathan C. ;

Schneider, Jurgen E. ;

Wang, Lai Mun ;

Delaney, David W. ;

Fleming, Ken A. ;

Robson, Matthew D. ;

Barnes, Eleanor ;

Neubauer, Stefan .

JOURNAL OF HEPATOLOGY, 2014, 60 (01) :69-77

[9] LEFT ATRIAL SIZE AND THE RISK OF STROKE AND DEATH - THE FRAMINGHAM HEART-STUDY [J].

BENJAMIN, EJ ;

DAGOSTINO, RB ;

BELANGER, AJ ;

WOLF, PA ;

LEVY, D .

CIRCULATION, 1995, 92 (04) :835-841

[10] Automated localization and quality control of the aorta in cine CMR can significantly accelerate processing of the UK Biobank population data [J].

Biasiolli, Luca ;

Hann, Evan ;

Lukaschuk, Elena ;

Carapella, Valentina ;

Paiva, Jose M. ;

Aung, Nay ;

Rayner, Jennifer J. ;

Werys, Konrad ;

Fung, Kenneth ;

Puchta, Henrike ;

Sanghvi, Mihir M. ;

Moon, Niall O. ;

Thomson, Ross J. ;

Thomas, Katharine E. ;

Robson, Matthew D. ;

Grau, Vicente ;

Petersen, Steffen E. ;

Neubauer, Stefan ;

Piechnik, Stefan K. .

PLOS ONE, 2019, 14 (02)

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