Angiotensin II-induced smooth muscle cell migration is mediated by LDL receptor-related protein 1 via regulation of matrix metalloproteinase 2 expression

被引：14
|
作者：
Jung, Hae Ok [1 ]
Uhm, Jae Sun [1 ]
Seo, Suk Min [1 ]
Kim, Jee Hee [1 ]
Youn, Ho-Joong [1 ]
Baek, Sang Hong [1 ]
Chung, Wook Sung [1 ]
Seung, Ki Bae [1 ]
机构：
[1] Catholic Univ Korea, Ctr Cardiovasc, Seoul St Marys Hosp, Coll Med, Seoul 137701, South Korea
来源：
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 2010年 / 402卷 / 04期
关键词：
Smooth muscle cells; Migration; LRP1; Angiotensin II; Matrix metalloproteinase 2; UROKINASE RECEPTOR; ALPHA(2)-MACROGLOBULIN RECEPTOR; PLASMINOGEN-ACTIVATOR; VASCULAR WALL; INVASION; ATHEROSCLEROSIS; CARCINOMA; COMPLEX;
D O I：
10.1016/j.bbrc.2010.10.019
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Anglotensin II (Ang II) one of the main vasoactive hormones of the renin-angiotensin system contributes to the development and progression of atherosclerosis by inducing vascular smooth muscle cells (VSMCs) migration Although previous studies have shown that Ang II upregulates low density lipoprotein receptor-related protein 1 (LRP1) expression in VSMCs and increases VSMCs migration the role of LRP1 in Ang II-induced VSMCs migration remains unclear Here we reveal a novel mechanism by which LRP1 induces the expression of matrix metalloproteinase 2 (MMP2) and thereby promotes the migration of rat aortic SMCs (RAoSMCs) Knockdown of LRP1 expression greatly decreased RAoSMCs migration which was rescued by forced expression of a functional LRP1 minireceptor suggesting that LRP1 is a key regulator of Ang II-induced RAoSMCs migration Inhibition of ligand binding to LRP1 by the specific antagonist receptor-associated protein (RAP) also led to reduced RAoSMCs migration Because MMPs play critical roles in RAoSMCs migration we examined the expression of several MMPs and found that the expression of functional MMP2 was selectively increased by Ang II treatment and decreased in LRP1-knockdown RAoSMCs More interestingly reduced MMP2 expression in LRP1-knockdown cells was completely rescued by exogenous expression of mLRP4 suggesting that MMP2 is a downstream regulator of LRP1 in Ang II-induced RAoSMCs migration Together our data strongly suggest that LRP1 promotes the migration of RAoSMCs by regulating the expression and function of MMP2 (C) 2010 Elsevier Inc All rights reserved
引用
收藏
页码：577 / 582
页数：6
相关论文
共 50 条
  • [1] Candesartan inhibitors angiotensin ii-induced matrix metalloproteinase 2 activation in human aortic smooth muscle cells via angiotensin II type 1 Receptor
    Wang, Chunmao
    Tian, Chuan
    Liu, Penghong
    Liu, Wenzhi
    Chang, Qian
    CARDIOLOGY, 2014, 129 : 51 - 51
  • [2] Contrasting effects of plasminogen activators, urokinase receptor, and LDL receptor-related protein on smooth muscle cell migration and invasion
    Okada, SS
    Grobmyer, SR
    Barnathan, ES
    ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 1996, 16 (10) : 1269 - 1276
  • [3] Angiotensin II-induced protein kinase D activation is regulated by protein kinase Cδ and mediated via the angiotensin II type 1 receptor in vascular smooth muscle cells
    Tan, MQ
    Xu, XM
    Ohba, M
    Cui, MZ
    ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 2004, 24 (12) : 2271 - 2276
  • [4] Role of receptor tyrosine kinase transactivation in angiotensin II-induced vascular smooth muscle cell migration
    Cruzado, MC
    Ibañez, JE
    Miatello, RM
    Risler, NR
    JOURNAL OF HYPERTENSION, 2004, 22 : S112 - S112
  • [5] Smooth Muscle Cell Deletion of Low-Density Lipoprotein Receptor-Related Protein 1 Augments Angiotensin II-Induced Superior Mesenteric Arterial and Ascending Aortic Aneurysms
    Davis, Frank M.
    Rateri, Debra L.
    Balakrishnan, Anju
    Howatt, Deborah A.
    Strickland, Dudley K.
    Muratoglu, Selen C.
    Haggerty, Christopher M.
    Fornwalt, Brandon K.
    Cassis, Lisa A.
    Daugherty, Alan
    ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 2015, 35 (01) : 155 - 162
  • [6] Angiotensin-(1-7) regulates angiotensin II-induced matrix metalloproteinase-8 in vascular smooth muscle cells
    Zhang, Feng
    Li, Sufang
    Song, Junxian
    Liu, Jun
    Cui, Yuxia
    Chen, Hong
    ATHEROSCLEROSIS, 2017, 261 : 90 - 98
  • [7] ANGIOTENSIN II-INDUCED MATRIX METALLOPROTEINASE-8 IS REGULATED BY ANGIOTENSIN-(1-7) IN VASCULAR SMOOTH MUSCLE CELLS
    Zhang, Feng
    Li, Sufang
    Song, Junxian
    Liu, Jun
    Cui, Yuxia
    Chen, Hong
    ATHEROSCLEROSIS, 2017, 263 : E68 - E68
  • [8] Angiotensin-(1-7) Inhibits Angiotensin II-Induced Matrix Metalloproteinase-8 in Vascular Smooth Muscle Cells
    Zhang, Feng
    Li, Sufang
    Song, Juxian
    Chen, Hong
    JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2017, 70 (16) : C23 - C24
  • [9] Regulation of angiotensin II type 1 receptor mRNA and protein in angiotensin II-induced hypertension
    Harrison-Bernard, LM
    El-Dahr, SS
    O'Leary, DF
    Navar, LG
    HYPERTENSION, 1999, 33 (01) : 340 - 346
  • [10] Angiotensin II-induced vascular pathologies in LDL receptor null mice are mediated by the angiotensin II type 1a receptor
    Rateri, D
    Cassis, L
    Daugherty, A
    ATHEROSCLEROSIS SUPPLEMENTS, 2003, 4 (02) : 318 - 318
12345