The effect of some 2-substituted quinolines isolated from Galipea longiflora on Plasmodium vinckei petteri infected mice

被引：50

作者：

Gantier, JC

Fournet, A

Munos, MH

Hocquemiller, R

机构：

[1] INST FRANCAIS RECH SCI DEV COOPERAT,ASUNCION,PARAGUAY

[2] UNIV PARIS SUD,FAC PHARM,LAB BIOL & CONTROLE ORGANISMS PARASITES,F-92296 CHATENAY MALABRY,FRANCE

[3] FAC PHARM CHATENAY MALABRY,CNRS,LAB PHARMACOGNOSIE,F-92296 CHATENAY MALABRY,FRANCE

[4] FAC PHARM CHATENAY MALABRY,CNRS,CHIM ORGAN LAB,F-92296 CHATENAY MALABRY,FRANCE

来源：

PLANTA MEDICA | 1996年 / 62卷 / 03期

关键词：

D O I：

10.1055/s-2006-957883

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

We have evaluated the in vivo antiplasmodial activity of six 2-substituted quinolines and a total alkaloidal extract of Galipea longiflora. BALB/c mice infected with Plasmodium vinckei petteri were treated orally at single dose of 50 mg/kg with quinolines or extract. Contrary to the previous results obtained with the Leishmania murine infection, 2-n-pentylquinoline showed activity against P. vinckei petteri. This result seems to confirm the antimalarial efficacy of infused stem bark of G. longiflora.

引用

页码：285 / 286

页数：2