Neutralizing HIV antibodies:: Do they really protect?

被引：3
|
作者：
Jülg, B [1 ]
Goebel, FD [1 ]
机构：
[1] Univ Munich, Dept Infect Dis, Med Poliklin, D-80336 Munich, Germany
来源：
INFECTION | 2005年 / 33卷 / 5-6期
关键词：
D O I：
10.1007/s15010-005-6505-y
中图分类号：
R51 [传染病];
学科分类号：
100401 ;
摘要：
Neutralizing antibodies work as a second line of defence. They are detected more or less in nearly every HIV-1-infected individual. 2G12, 2F5 and 4E10 represent antibodies with broadly neutralizing activity made from B cells of HIV-1-infected humans. Unfortunately these antibodies are extremely rare and all attempts to elicit them via vaccine immunogens have failed. The discovery of autoreactive features of these antibodies could now explain why. Additionally, new results show the delayed viral rebound under antibody treatment in some HIV-1-infected individuals.
引用
收藏
页码：405 / 407
页数：3
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