Tacrolimus Therapy in Steroid-Refractory Ulcerative Colitis: A Review

被引：34
|
作者：
Wu, Biyu [1 ]
Tong, Jinglu [1 ]
Ran, Zhihua [1 ]
机构：
[1] Shanghai Jiao Tong Univ, Sch Med, Affiliated Renji Hosp, Shanghai, Peoples R China
来源：
INFLAMMATORY BOWEL DISEASES | 2020年 / 26卷 / 01期
关键词：
tacrolimus; steroid-refractory ulcerative colitis; calcineurin inhibitor; CYP3A5; genotype; induction of remission; INFLAMMATORY-BOWEL-DISEASE; NF-KAPPA-B; ORAL TACROLIMUS; EFFICACY; KINASE; FK506; MANAGEMENT; INDUCTION; SAFETY; PHARMACOKINETICS;
D O I：
10.1093/ibd/izz068
中图分类号：
R57 [消化系及腹部疾病];
学科分类号：
摘要：
Inflammatory bowel diseases are known for a chronic inflammatory process of the gastrointestinal tract and include Crohn's disease and ulcerative colitis (UC). Patients who are dependent on or resistant to corticosteroids account for about 20% of severe UC patients. Tacrolimus is a calcineurin inhibitor that has recently been used in the treatment of steroid-refractory ulcerative colitis. Tacrolimus has been demonstrated to have remarkable therapeutic efficacy in UC patients, without increased risk of severe adverse effects such as induction of remission and maintenance therapy. This article reviews the mechanism of action, pharmacogenetics, efficacy, and safety of tacrolimus for patients with steroid-refractory ulcerative colitis.
引用
收藏
页码：24 / 32
页数：9
相关论文
共 50 条
  • [1] Sequential rescue therapy in steroid-refractory ulcerative colitis
    Paolo Gionchetti
    Fernando Rizzello
    Nature Reviews Gastroenterology & Hepatology, 2014, 11 : 521 - 523
  • [2] A Retrospective Comparative Study of Tacrolimus and Infliximab in Steroid-Refractory Ulcerative Colitis
    Mizuno, Shinta
    Matsuoka, Katsuyoshi
    Inoue, Nagamu
    Naganuma, Makoto
    Hisamatsu, Tadakazu
    Yajima, Tomoharu
    Kanai, Takanori
    Ogata, Haruhiko
    Iwao, Yasushi
    Hibi, Toshifumi
    INFLAMMATORY BOWEL DISEASES, 2012, 18 : S48 - S48
  • [3] Efficacy and Safety of Tacrolimus Therapy for Severe and Steroid-refractory Ulcerative Colitis: A Systematic Review and Meta-analysis
    Komaki, Yuga
    Komaki, Fukiko
    Sakuraba, Atsushi
    AMERICAN JOURNAL OF GASTROENTEROLOGY, 2015, 110 : S828 - S829
  • [4] Cyclosporin for steroid-refractory ulcerative colitis
    Actis, GC
    AMERICAN JOURNAL OF GASTROENTEROLOGY, 2000, 95 (03): : 830 - 830
  • [5] Letter: short-term efficacy of tacrolimus in steroid-refractory ulcerative colitis
    Hirai, F.
    Takatsu, N.
    Matsui, T.
    ALIMENTARY PHARMACOLOGY & THERAPEUTICS, 2013, 37 (04) : 501 - 501
  • [6] Commentary: short-term efficacy of tacrolimus in steroid-refractory ulcerative colitis
    Bjorck, S.
    Enochsson, L.
    Svanvik, J.
    ALIMENTARY PHARMACOLOGY & THERAPEUTICS, 2013, 37 (04) : 493 - 494
  • [7] Performance of tacrolimus in hospitalized patients with steroid-refractory acute severe ulcerative colitis
    Peter Hoffmann
    Cyrill Wehling
    Johannes Krisam
    Jan Pfeiffenberger
    Nina Belling
    Annika Gauss
    Department of
    World Journal of Gastroenterology, 2019, (13) : 1603 - 1617
  • [8] Performance of tacrolimus in hospitalized patients with steroid-refractory acute severe ulcerative colitis
    Hoffmann, Peter
    Wehling, Cyrill
    Krisam, Johannes
    Pfeiffenberger, Jan
    Belling, Nina
    Gauss, Annika
    WORLD JOURNAL OF GASTROENTEROLOGY, 2019, 25 (13) : 1603 - 1617
  • [9] IBD Sequential rescue therapy in steroid-refractory ulcerative colitis
    Gionchetti, Paolo
    Rizzello, Fernando
    NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY, 2014, 11 (09) : 521 - 523
  • [10] Rebamipide therapy shows promise for steroid-refractory ulcerative colitis
    Nature Clinical Practice Gastroenterology & Hepatology, 2007, 4 (5): : 243 - 243
12345