Acylphloroglucinol derivatives from Mahurea palustris

被引：7

作者：

Massiot, G ^{[1
]}

Long, C

David, B

Serrano, MJ

Daubié, F

Alby, F

Ausseil, F

Knibiehler, M

Moretti, C

Hoffmann, JS

Cazaux, C

Lavaud, C

机构：

[1] CNRS, Joint Serv Unit 2597, Pierre Fabre Sci & Technol Inst Med Toulouse, F-31432 Toulouse, France

[2] CNRS, Joint Serv Unit 2646, Pierre Fabre Sci & Technol Inst Med Toulouse, F-31432 Toulouse, France

[3] CNRS, Joint Res Unit 2587, Pierre Fabre Sci & Technol Inst Med Toulouse, F-31432 Toulouse, France

[4] IRD Ctr, IRD, Serv Unit 84, F-97323 Cayenne, France

[5] CNRS, Joint Res Unit 5089, Natl Ctr Sci Res, Inst Pharmacol & Struct Biol, F-31077 Toulouse, France

[6] Univ Reims, Lab Pharmacognosy, Natl Ctr Sci Res, Joint Res Unit 6013, F-51097 Reims, France

来源：

JOURNAL OF NATURAL PRODUCTS | 2005年 / 68卷 / 07期

关键词：

D O I：

10.1021/np049676o

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Five new acylphloroglucinol derivatives, mahureones A-E (1, 3-6), have been isolated from the leaves of Mahurea palustris, and their structures determined by spectroscopic means. During the isolation process, several byproducts (7-9) were formed by reaction of one of the isoprenyl side chains with TFA, water, and acetonitrile. All the compounds were assayed for their ability to inhibit human DNA polymerase beta. The most active compounds, mahureones A (1) and D (5), exhibited IC50 values in the 10 mu M range.

引用

页码：979 / 984

页数：6

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