Impact of Maternal Obesity on Fetal Programming of Cardiovascular Disease

被引：58
|
作者：
Roberts, Victoria H. J. [1 ]
Frias, Antonio E. [1 ,2 ]
Grove, Kevin L. [1 ]
机构：
[1] Oregon Natl Primate Res Ctr, Div Diabet Obes & Metab, Beaverton, OR 97006 USA
[2] Oregon Hlth & Sci Univ, Dept Obstet & Gynecol, Portland, OR 97201 USA
来源：
PHYSIOLOGY | 2015年 / 30卷 / 03期
基金：
美国国家卫生研究院;
关键词：
CELL-CYCLE ACTIVITY; BODY-MASS INDEX; BLOOD-PRESSURE; TROPHOBLAST INVASION; NATRIURETIC-PEPTIDE; NONHUMAN PRIMATE; ADIPOSE-TISSUE; RAT MODEL; PREGNANCY; ARTERIAL;
D O I：
10.1152/physiol.00021.2014
中图分类号：
Q4 [生理学];
学科分类号：
071003 ;
摘要：
The in utero environment is a key determinant of long-term health outcomes; poor maternal metabolic state and placental insufficiency are strongly associated with these long-term health risks. Human epidemiological studies link maternal obesity and offspring cardiovascular disease in later life, but mechanistic studies in animal models are limited. Here, we review the literature pertaining to maternal consequences of obesity during pregnancy and the subsequent impact on fetal cardiovascular development.
引用
收藏
页码：224 / 231
页数：8
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