The Itch to degrade ROR-γt

被引：7
|
作者：
Rutz, Sascha [1 ]
Ouyang, Wenjun [2 ]
机构：
[1] Genentech Inc, Dept Canc Immunol, San Francisco, CA 94080 USA
[2] Amgen Inc, Dept Inflammat & Oncol, San Francisco, CA USA
来源：
NATURE IMMUNOLOGY | 2016年 / 17卷 / 08期
关键词：
IMMUNE REGULATION; UBIQUITIN SYSTEM;
D O I：
10.1038/ni.3516
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
The E3 ubiquitin ligase Itch limits interleukin 17A (IL-17A)-mediated intestinal inflammation by targeting the transcription factor ROR-gamma t for proteasomal degradation.
引用
收藏
页码：898 / +
页数：4
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