Effect of simvastatin on the pharmacokinetics of anastrozole

被引：5
|
作者：
Bao, Ting [1 ]
Blackford, Amanda L. [1 ]
Stearns, Vered [1 ]
机构：
[1] Johns Hopkins Sch Med, Sidney Kimmel Comprehens Canc Ctr, Baltimore, MD 21231 USA
来源：
BREAST CANCER RESEARCH AND TREATMENT | 2012年 / 131卷 / 02期
关键词：
Simvastastin; Anastrozole; Breast cancer; Chemoprevention; EARLY BREAST-CANCER; POSTMENOPAUSAL WOMEN; COMBINATION; TAMOXIFEN; TRIAL;
D O I：
10.1007/s10549-011-1859-6
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
We have prospectively tested the effects of simvastatin on the pharmacokinetics of anastrozole and on estrogen concentrations in postmenopausal women with hormone receptor-positive breast cancer who were receiving adjuvant anastrozole. Following 14 days of simvastatin, we did not observe a significant change in plasma concentrations of anastrozole or hydroxyanastrozole in nine evaluable women. Likewise, we did not observe any statistically significant change in serum concentrations of either estradiol, which remained in the undetectable range, or estrone sulfate. Simvastatin and anastrozole may be safely co-administered. Pharmacokinetic results suggest that simvastatin is not likely to compromise the activity of anastrozole.
引用
收藏
页码：709 / 711
页数：3
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