The association between aortic augmentation index and cardiovascular risk factors in a large unselected population

被引:43
|
作者
Janner, J. H. [1 ]
Godtfredsen, N. S. [2 ]
Ladelund, S. [3 ]
Vestbo, J. [4 ]
Prescott, E. [5 ,6 ]
机构
[1] Hvidovre Univ Hosp, Dept Cardiol & Resp Med, DK-2650 Hvidovre, Denmark
[2] Bispebjerg Hosp, Dept Resp Med, Copenhagen, Denmark
[3] Hvidovre Univ Hosp, Clin Res Ctr, DK-2650 Hvidovre, Denmark
[4] Univ Manchester, Resp Res Grp, Manchester Acad Hlth Sci Ctr, Univ Hosp S Manchester NHS Fdn Trust, Manchester, Lancs, England
[5] Bispebjerg Hosp, Dept Cardiol, Copenhagen, Denmark
[6] Bispebjerg Hosp, Copenhagen City Heart Study, Copenhagen, Denmark
关键词
AIx; augmentation index; cardiovascular risk; epidemiology; ARTERIAL WAVE REFLECTIONS; GENERALIZED TRANSFER-FUNCTION; COLLABORATIVE TRIAL ACCT; HEART-DISEASE RISK; BLOOD-PRESSURE; PULSE PRESSURE; ELDERLY-MEN; STIFFNESS; FORM; EVENTS;
D O I
10.1038/jhh.2011.59
中图分类号
R6 [外科学];
学科分类号
1002 ; 100210 ;
摘要
The augmentation index (AIx) is a measure of systemic arterial stiffness, and previous studies have demonstrated an association between AIx and risk factors of cardiovascular disease (CVD). However, there is limited knowledge about the age and gender differences of the observed associations. Therefore, the aim of the present study is to examine the association's consistency at different ages and to see if the associations are the same in men and women. This study is based on 3432 subjects from The Copenhagen City Heart Study, a prospective epidemiological survey of a representative population in Denmark. All subjects had AIx measured non-invasively by the SphygmoCor device (SphygmoCor, West Ryde, Australia). To analyse the association between AIx and CVD risk factors multiple linear regression analyses were used stratified by gender and age. The main determinants of AIx were age, heart rate, height and systolic blood pressure in both age groups with few gender differences. Associations between AIx and cardiovascular risk factors further differed by age: In young subjects AIx was associated with cholesterol, high-sensitive C-reactive protein, current smoking, low weight, poor education and physical inactivity, whereas in subjects above age 60 AIx was associated with weight and current smoking in men. We found a modest association between AIx and traditional CVD risk factors and the association attenuated in subjects >60 years. Further longitudinal studies are needed to determine whether AIx is primarily a marker of CVD in younger subjects. Journal of Human Hypertension (2012) 26, 476-484; doi:10.1038/jhh.2011.59; published online 9 June 2011
引用
收藏
页码:476 / 484
页数:9
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