CircRNA: A novel biomarker for forensic age estimation?

被引：1
|
作者：
Wang, Junyan [1 ]
Fu, Guangping [1 ]
Wang, Qian [1 ]
Cong, Bin [1 ]
Li, Shujin [1 ]
机构：
[1] Hebei Med Univ, Dept Forens Med, Hebei Key Lab Forens Med, 361 Zhong Shan Rd, Shijiazhuang, Hebei, Peoples R China
来源：
FORENSIC SCIENCE INTERNATIONAL GENETICS SUPPLEMENT SERIES | 2019年 / 7卷 / 01期
基金：
中国国家自然科学基金;
关键词：
D O I：
10.1016/j.fsigss.2019.10.068
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
Aging is a complex process and is associated with various molecular regulations on DNA or RNA levels. In forensic science, accurate age estimation of an unknown individual can be of extremely important. Recent years, age-related molecular biomarkers have been proposed as indicators of chronological age. There were studies showing that circular RNAs (circRNAs) change significantly during aging. Here, the correlation of circRNAs expression levels and age was investigated by detecting circRNA levels in peripheral whole blood utilizing next-generation RNA sequencing (RNA-seq). We suggest that circRNA can be a novel biomarker for forensic age estimation.
引用
收藏
页码：504 / 506
页数：3
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