Application of Box-Behnken experimental design to optimize the magnetic actuation parameters' for driving fluid in micro pump

Microfluidics pump technology characterized by the parameters of pump components and fluids at the submillimetre scale, has shown considerable promise for improving diagnostics and biology research. The main work of this paper is applying Box-Behnken design to optimize actuator model focuses on the flow rate in electromagnetic actuation pump. The objective of the current study is to develop an extraction method for assessing pump output parameters using response surface methodology (RSM) optimization. A three-level three-factor Box-Behnken design (BBD) was applied for investigating the interactions between the critical variables including frequency, voltage and location to achieve the desired flow rate. Analysis of variance indicated that the proposed quadratic model successfully interpreted the experimental data with coefficients of determination of R-2 = 0.55 and adjusted R-2 = 0.15. Through this model, we can predict and control the flow rate output under different conditions. It may explain about biofluids interaction with vessels wall such as actuator, which give rise to the flow characteristic of the transport role and functionality.