Novel anti-PD-L1/IL-15 bifunctional immunotherapeutics potentiates antitumor immunity

被引:0
|
作者
Wu, Yan
Zhong, Zhaojing
Martomo, Stella
Lu, Dan
Zhang, Haifan
Polonskaya, Zhanna
Luna, Xenia
Zhang, Zhikai
Wang, Zhun
Liu, Leo
Patel, Jeegar
Tonra, James
Li, Henry
Witte, Larry
Waksal, Sam
Zhu, Zhenping
机构
关键词
D O I
10.1158/1538-7445.AM2016-4997
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
4997
引用
收藏
页数:3
相关论文
共 50 条
  • [1] A novel anti-PD-L1/IL-15 immunocytokine overcomes resistance to PD-L1 blockade and elicits potent antitumor immunity
    Shi, Wenqiang
    Lv, Liangyin
    Liu, Nan
    Wang, Hui
    Wang, Yang
    Zhu, Wen
    Liu, Zexin
    Zhu, Jianwei
    Lu, Huili
    MOLECULAR THERAPY, 2023, 31 (01) : 66 - 77
  • [2] Functional and mechanistic advantage of the use of a bifunctional anti-PD-L1/IL-15 superagonist
    Knudson, Karin M.
    Hicks, Kristin C.
    Ozawa, Yohei
    Schlom, Jeffrey
    Gameiro, Sofia R.
    JOURNAL FOR IMMUNOTHERAPY OF CANCER, 2020, 8 (01)
  • [3] Next-generation anti-PD-L1/IL-15 immunocytokine elicits superior antitumor immunity in cold tumors with minimal toxicity
    Shi, Wenqiang
    Liu, Nan
    Liu, Zexin
    Yang, Yuqi
    Zeng, Qiongya
    Wang, Yang
    Song, Luyao
    Hu, Fang
    Fu, Jin
    Chen, Junsheng
    Wu, Mingyuan
    Zhou, Lin
    Zhu, Fengping
    Gong, Likun
    Zhu, Jianwei
    Jiang, Long
    Lu, Huili
    CELL REPORTS MEDICINE, 2024, 5 (05)
  • [4] Mechanisms involved in IL-15 superagonist enhancement of anti-PD-L1 therapy
    Knudson, Karin M.
    Hicks, Kristin C.
    Alter, Sarah
    Schlom, Jeffrey
    Gameiro, Sofia R.
    JOURNAL FOR IMMUNOTHERAPY OF CANCER, 2019, 7
  • [5] ANTI-PD-L1/IL-15 KD033 ACTIVATED MACROPHAGES AND INDUCED ANTI-TUMOR IMMUNITY IN THE TUMOR-MICROENVIRONMENT
    Martomo, Stella
    Wang, George
    Polonskaya, Zhanna
    Luna, Xenia
    Lu, Dan
    Patel, Jeegar
    JOURNAL FOR IMMUNOTHERAPY OF CANCER, 2021, 9 : A681 - A681
  • [6] Targeting IL-33 reprograms the tumor microenvironment and potentiates antitumor response to anti-PD-L1 immunotherapy
    Nan, Yanyang
    Bai, Yu
    Hu, Xiaozhi
    Zhou, Kaicheng
    Wu, Tao
    Zhu, An
    Li, Mengyang
    Dou, Zihan
    Cao, Zhonglian
    Zhang, Xumeng
    Xu, Shuwen
    Zhang, Yuanzhen
    Lin, Jun
    Zeng, Xian
    Fan, Jiajun
    Zhang, Xuyao
    Wang, Xuebin
    Ju, Dianwen
    JOURNAL FOR IMMUNOTHERAPY OF CANCER, 2024, 12 (09)
  • [7] Commensal Bifidobacterium promotes antitumor immunity and facilitates anti-PD-L1 efficacy
    Sivan, Ayelet
    Corrales, Leticia
    Hubert, Nathaniel
    Williams, Jason B.
    Aquino-Michaels, Keston
    Earley, Zachary M.
    Benyamin, Franco W.
    Lei, Yuk Man
    Jabri, Bana
    Alegre, Maria-Luisa
    Chang, Eugene B.
    Gajewski, Thomas F.
    SCIENCE, 2015, 350 (6264) : 1084 - 1089
  • [8] Irradiation and anti-PD-L1 treatment synergistically promote antitumor immunity in mice
    Deng, Liufu
    Liang, Hua
    Burnette, Byron
    Beckett, Michael
    Darga, Thomas
    Weichselbaum, Ralph R.
    Fu, Yang-Xin
    JOURNAL OF CLINICAL INVESTIGATION, 2014, 124 (02): : 687 - 695
  • [9] A novel, tumor-targeted immunocytokine comprising an anti-PD-L1 Affimer® fused to IL-15 exhibits potent anti-tumor activity
    Juskaite, Victoria
    Avisetti, Deepa
    Jones, David H.
    Sobri, Ahmad
    Billenness, Gregory
    Buist, Hanna
    Tong, Tik Nga
    Yahya, Norhakim
    McLaughlin, Fiona
    MOLECULAR CANCER THERAPEUTICS, 2023, 22 (12)
  • [10] Evaluation of the anti-tumour efficacy and immune effects of N-809, a novel IL-15 superagonist/anti-PD-L1 bispecific agent
    Hicks, K. C.
    Knudson, K. M.
    Ozawa, Y.
    Schlom, J.
    Gameiro, S. R.
    ANNALS OF ONCOLOGY, 2019, 30 : 500 - 500