Ent-kaurane and ent-abietane diterpenoids from Isodon phyllostachys

被引：1
|
作者：
Yang, Jin [1 ,2 ]
An, Yaqi [1 ,2 ]
Wu, Haiyan [1 ,2 ]
Liu, Miao [1 ,2 ]
Wang, Weiguang [1 ]
Du, Xue [1 ]
Li, Yan [1 ]
Pu, Jianxin [1 ]
Sun, Handong [1 ]
机构：
[1] Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Peoples R China
[2] Univ Chinese Acad Sci, Beijing 100049, Peoples R China
来源：
SCIENCE CHINA-CHEMISTRY | 2016年 / 59卷 / 09期
基金：
中国国家自然科学基金; 中国科学院西部之光基金;
关键词：
Isodon phyllostachys; diterpenoid; ent-kaurane; ent-abietane;
D O I：
10.1007/s11426-016-0049-4
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Four new diterpenoids, phyllostachysins I-L (1-4), along with a known one, hebeiabinin B (5), were isolated from the aerial parts of Isodon phyllostachys (I. phyllostachys). Compounds 1 and 2 feature an ent-kaurane backbone, and 3, 4 and 5 bear an ent-abietane skeleton. Their structures were elucidated by means of spectroscopic analysis. Compounds 3 and 4 exhibited significant cytotoxic activity against human tumor cell lines (HL-60, SMMC-7721, A-549, MCF-7 and SW-480), and strongly inhibited NO production in LPS-stimulated RAW264.7 cells.
引用
收藏
页码：1211 / 1215
页数：5
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