Engineering a 2D protein-DNA crystal

被引：147

作者：

Malo, J

Mitchell, JC

Vénien-Bryan, C

Harris, JR

Wille, H

Sherratt, DJ

Turberfield, AJ

机构：

[1] Univ Oxford, Dept Phys, Clarendon Lab, Oxford OX1 3PU, England

[2] Univ Oxford, Dept Biochem, Lab Mol Biophys, Oxford OX1 3QU, England

[3] Johannes Gutenberg Univ Mainz, Inst Zool, D-55099 Mainz, Germany

[4] Univ Calif San Francisco, Dept Neurol, San Francisco, CA 94143 USA

[5] Univ Calif San Francisco, Inst Neurodegenerat Dis, San Francisco, CA 94143 USA

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2005年 / 44卷 / 20期

基金：

英国惠康基金; 英国工程与自然科学研究理事会;

关键词：

DNA; electron microscopy; nanostructures; proteins; self-assembly;

D O I：

10.1002/anie.200463027

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

(Figure Presented) Weaving with DNA: A DNA-binding protein was used to control the structure of a self-assembled 2D crystal. In the absence of protein, four oligonucleotides hybridize to form a Kagome lattice of interwoven double helices with p3 symmetry (see image). Addition of protein RuvA during assembly changes the symmetry and connectivity to give a DNA-protein crystal with an approximately square unit cell. © 2005 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

页码：3057 / 3061

页数：5

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