Soluble Guanylate Cyclase Stimulators in Heart Failure

被引：12
|
作者：
Kansakar, Sajog [1 ]
Guragain, Ashish [1 ]
Verma, Deepak [2 ]
Sharma, Prabhat [1 ,3 ]
Dhungana, Bibek [4 ]
Bhattarai, Bidit [5 ]
Yadav, Sunil [6 ]
Gautam, Ishant [7 ]
机构：
[1] Manipal Coll Med Sci, Internal Med, Pokhara, Nepal
[2] Calif Inst Behav Neurosci & Psychol, Internal Med Family Med, Fairfield, CA USA
[3] Shankarapur Hosp, Internal Med, Kathmandu, Nepal
[4] KIST Med Coll, Internal Med, Lalitpur, Nepal
[5] Venus Hosp, Internal Med, Kathmandu, Nepal
[6] Topa Primary Hlth Ctr, Internal Med, Rajbiraj, Nepal
[7] Bhaktapur Hosp, Internal Med, Bhaktapur, Nepal
来源：
CUREUS JOURNAL OF MEDICAL SCIENCE | 2021年 / 13卷 / 09期
关键词：
heart failure with reduced ejection fraction (hfref); heart failure with preserved ejection fraction (hfpef); heart failure; guanylate cyclase stimulators; vericiguat; PRESERVED EJECTION FRACTION; NITRIC-OXIDE; VERICIGUAT; PATHOPHYSIOLOGY; CAPACITY; PLACEBO;
D O I：
10.7759/cureus.17781
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Heart failure has a high global burden of morbidity and mortality. Despite significant advances in medical management of heart failure, the prognosis remains poor. This justifies the search for newer therapeutic agents. Recently, soluble guanylate stimulators have demonstrated favorable results in clinical trials. This article aims to summarize the guanylate cyclase signaling pathway, the role of soluble guanylate cyclase stimulators in heart failure, and data from recent clinical trials of these drugs. We concluded that soluble guanylate cyclase stimulators have significant benefits in reducing hospitalizations in patients with heart failure with reduced ejection fraction that are at high risk of cardiovascular events. There appears to be no benefit of these drugs in patients with heart failure with preserved ejection fraction.
引用
收藏
页数：7
相关论文
共 50 条
  • [1] Soluble Guanylate Cyclase Activators and Stimulators in Patients with Heart Failure
    Liang, Wei-Lin
    Liang, Bo
    CURRENT CARDIOLOGY REPORTS, 2023, 25 (06) : 607 - 613
  • [2] Soluble Guanylate Cyclase Activators and Stimulators in Patients with Heart Failure
    Wei-Lin Liang
    Bo Liang
    Current Cardiology Reports, 2023, 25 : 607 - 613
  • [3] SAFETY AND EFFICACY OF SOLUBLE GUANYLATE CYCLASE STIMULATORS IN PATIENTS WITH HEART FAILURE
    Zghouzi, Mohamed
    Ullah, Waqas
    Ahmad, Bachar
    Sattar, Yasar
    Zaher, Nathan
    Mir, Tanveer
    Elmakshbr, Nada
    Ali, Omar
    Gardi, Delair
    Hakim, Zaher
    Alraies, M. Chadi
    JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2021, 77 (18) : 772 - 772
  • [4] Soluble Guanylate Cyclase Stimulators: a Novel Treatment Option for Heart Failure Associated with Cardiorenal Syndromes?
    Dubin R.F.
    Shah S.J.
    Current Heart Failure Reports, 2016, 13 (3) : 132 - 139
  • [5] Soluble guanylate cyclase modulators in heart failure
    Mitrovic V.
    Jovanovic A.
    Lehinant S.
    Current Heart Failure Reports, 2011, 8 (1) : 38 - 44
  • [6] NO-independent stimulators of soluble guanylate cyclase
    Straub, A
    Stasch, JP
    Alonso-Alija, C
    Benet-Buchholz, J
    Ducke, B
    Feurer, A
    Fürstner, C
    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2001, 11 (06) : 781 - 784
  • [7] Soluble guanylate cyclase stimulators for cardiovascular disease
    Raghavan, Subharekha
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2017, 254
  • [8] Acidic triazoles as soluble guanylate cyclase stimulators
    Roberts, Lee R.
    Bradley, Paul A.
    Bunnage, Mark E.
    England, Katherine S.
    Fairman, David
    Fobian, Yvette M.
    Fox, David N. A.
    Gymer, Geoff E.
    Heasley, Steven E.
    Molette, Jerome
    Smith, Graham L.
    Schmidt, Michelle A.
    Tones, Michael A.
    Dack, Kevin N.
    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2011, 21 (21) : 6515 - 6518
  • [9] Soluble guanylate cyclase stimulators in patients with heart failure with reduced ejection fraction across the risk spectrum
    Butler, Javed
    Usman, Muhammad Shariq
    Anstrom, Kevin J.
    Blaustein, Robert O.
    Bonaca, Marc P.
    Ezekowitz, Justin A.
    Freitas, Cecilia
    Lam, Carolyn S. P.
    Lewis, Eldrin F.
    Lindenfeld, JoAnn
    McMullan, Ciaran J.
    Mentz, Robert J.
    O'Connor, Christopher
    Rosano, Giuseppe M. C.
    Ines Saldarriaga, Clara
    Senni, Michele
    Udelson, James
    Voors, Adriaan A.
    Zannad, Faiez
    EUROPEAN JOURNAL OF HEART FAILURE, 2022, 24 (11) : 2029 - 2036
  • [10] Stimulators and activators of soluble guanylate cyclase for urogenital disorders
    Fabiola Z. Mónica
    Edson Antunes
    Nature Reviews Urology, 2018, 15 : 42 - 54
12345