Cardiovascular risk of BRCA1/2 mutation carriers: A review

被引：23
|
作者：
van Westerop, L. L. M. [1 ]
Jong, M. Arts-de [1 ]
Hoogerbrugge, N. [2 ]
de Hullu, J. A. [1 ]
Maas, A. H. E. M. [3 ]
机构：
[1] Radboud Univ Nijmegen, Med Ctr, Dept Obstet & Gynaecol, Nijmegen, Netherlands
[2] Radboud Univ Nijmegen, Med Ctr, Dept Human Genet, Nijmegen, Netherlands
[3] Radboud Univ Nijmegen, Med Ctr, Dept Cardiol, Nijmegen, Netherlands
来源：
MATURITAS | 2016年 / 91卷
关键词：
BRCA; Cardiovascular disease; Salpingo-oophorectomy; Cardiotoxicity; Cardio-oncology; REDUCING SALPINGO-OOPHORECTOMY; DOUBLE-STRAND BREAKS; OVARIAN-CANCER; BILATERAL OOPHORECTOMY; LONG-TERM; MYOCARDIAL-INFARCTION; INSULIN-RESISTANCE; METABOLIC SYNDROME; HORMONE-THERAPY; EARLY MENOPAUSE;
D O I：
10.1016/j.maturitas.2016.06.012
中图分类号：
R592 [老年病学]; C [社会科学总论];
学科分类号：
03 ; 0303 ; 100203 ;
摘要：
BRCA1/2 mutation carriers are at high risk of breast and ovarian cancer. The number of studies on non cancer endpoints in BRCA1/2 mutation carriers is still limited. BRCA1/2 mutation carriers may be at higher cardiovascular risk due to early menopause after risk-reducing salpingo-oophorectomy and/or due to the potential cardiotoxic effects of breast cancer treatment (radiotherapy and chemotherapy). Moreover, BRCA genes have a role as a gatekeeper in cardiac function and structure, which may affect susceptibility to cardiac damage. Our goal is to review current knowledge of cardiovascular risk among BRCA1/2 mutation carriers. (C) 2016 Elsevier Ireland Ltd. All rights reserved.
引用
收藏
页码：135 / 139
页数：5
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