Therapy-induced senescence - an induced synthetic lethality in liver cancer?

被引：10

作者：

Wolter, Katharina ^{[1
,2
]}

Zender, Lars ^{[1
,2
,3
]}

机构：

[1] Univ Hosp Tubingen, Dept Med Oncol & Pneumol Internal Med 8, Tubingen, Germany

[2] Eberhard Karls Univ Tubingen, Cluster Excellence Image Guided & Functionally In, Tubingen, Germany

[3] German Canc Res Ctr, German Consortium Translat Canc Res DKTK, Partner Site Tubingen, Heidelberg, Germany

来源：

NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY | 2020年 / 17卷 / 03期

基金：

欧洲研究理事会;

关键词：

SURVEILLANCE; DISEASES; CELLS;

D O I：

10.1038/s41575-020-0262-3

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Cancer therapies, in addition to inducing cell death, can trigger cellular senescence of tumour cells, and factors secreted from senescent cells might negatively affect the tumour microenvironment. A new study by Wang et al. shows that eradication of therapy-induced senescent cells (senolysis) can improve the outcome of liver cancer therapy.

引用

页码：135 / 136

页数：2

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