Recovery of paraneoplastic hypercalcemia by sunitinib treatment for renal cell carcinoma: a case report and review of the literature

被引：8

作者：

Karaca, Halit ^{[1
]}

Lale, Ayhan ^{[2
]}

Dikilitas, Mustafa ^{[1
]}

Ozkan, Metin ^{[1
]}

Er, Ozlem ^{[1
]}

机构：

[1] Erciyes Univ, Dept Med Oncol, Fac Med, Kayseri, Turkey

[2] Erciyes Univ, Dept Internal Med, Fac Med, Kayseri, Turkey

来源：

MEDICAL ONCOLOGY | 2010年 / 27卷 / 03期

关键词：

Renal cell carcinoma; Paraneoplastic hypercalcemia; Sunitinib; TYROSINE KINASE INHIBITOR; GROWTH-FACTOR; SU11248; CANCER; INTERFERON; SURVIVAL;

D O I：

10.1007/s12032-009-9327-4

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Sunitinib is a novel oral multitargeted tyrosine kinase inhibitor. It has higher response rates and progression-free survival in patients with metastatic renal cell carcinoma (RCC) when compared with standard chemotherapy and interferon-a. We report a case of paraneoplastic hypercalcemia, resistant to conventional treatment but recovers by sunitinib treatment as the first case in the literature, in a 33-years-old man with metastatic RCC. At the sixth month of follow-up period, in this case, serum calcium level was still in normal ranges. Besides sunitinib is effective in symptom control, it is also helpful in management of paraneoplastic hypercalcemia, a life-threatening entity.

引用

页码：1023 / 1026

页数：4

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