Synthetic Studies toward the C14-C29 Fragment of Mirabalin

被引：13

作者：

Cornil, Johan ^{[1
]}

Echeverria, Pierre-Georges ^{[2
]}

Reymond, Sebastien ^{[1
]}

Phansavath, Phannarath ^{[2
]}

Ratovelomanana-Vidal, Virginie ^{[2
]}

Guerinot, Amandine ^{[1
]}

Cossy, Janine ^{[1
]}

机构：

[1] PSL Res Univ, ESPCI Paris, CNRS,UMR 8231, Lab Chim Organ,Inst Chem Biol & Innovat CBI, 10 Rue Vauquelin, F-75231 Paris 05, France

[2] PSL Res Univ, Chim ParisTech, CNRS, Inst Rech Chim Paris, F-75005 Paris, France

来源：

ORGANIC LETTERS | 2016年 / 18卷 / 18期

关键词：

POTENT CYTOTOXIC MACROLIDE; FORMAL TOTAL SYNTHESIS; SWINHOLIDE-A; ABSOLUTE STEREOSTRUCTURE; DIMERIC MACROLIDE; SUPERSTOLIDE-A; RIFAMYCIN-S; SPONGE; STRATEGY; SUBUNITS;

D O I：

10.1021/acs.orglett.6b02162

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A convergent synthesis of one isomer of the C14-C29 fragment of mirabalin is disclosed. The key steps include a Marshall allenylation, a Mukaiyama aldol reaction and a Crimmins aldolization, which allow the control of 10 out of 25 stereogenic centers present in the molecule.

引用

页码：4534 / 4537

页数：4

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