A New Method for the synthesis of 1,3,4-Thiadiazine Derivatives

被引：2
|
作者：
Cao, Xueli [1 ]
Guo, Xiao [2 ]
机构：
[1] Taishan Univ, Coll Chem & Chem Engn, Tai An 271000, Shandong, Peoples R China
[2] Jewim Pharmaceut Shandong Co Ltd, Tai An 271000, Shandong, Peoples R China
来源：
CHINESE JOURNAL OF ORGANIC CHEMISTRY | 2020年 / 40卷 / 04期
关键词：
alpha-chloroindole; 1,3,4-thiadiazine; synthesis; FACILE SYNTHESIS; ANTIMICROBIAL ACTIVITY; IMINES;
D O I：
10.6023/cjoc201908005
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
An efficient method for the preparation of 1,3,4-thiadiazine derivatives has been reported. With 2,5-dihydroxy1,4-dithiane and alpha-chloroindole containing different substituents, 13 compounds were synthesized. The yields of the compounds were above 82% except (E)-4-phenyl2-stY1)71-5,6-dilwdre-411-1,3,4-illiadiazin-5-01 (31n)- flirtbemiere, the ProPosed reaction mechanism was discussed. The developed method features simple operation, mild reaction condition, environmentally friendly, high yield and a broad range of substrate applicability. It provides a new way for the synthesis of 1,3,4-thiadiazine derivatives.
引用
收藏
页码：1050 / 1054
页数：5
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