Urine pH is an indicator of dietary acid-base load, fruit and vegetables and meat intakes: results from the European Prospective Investigation into Cancer and Nutrition (EPIC)-Norfolk population study

被引:135
|
作者
Welch, Ailsa A. [1 ]
Mulligan, Angela [1 ]
Bingham, Sheila A. [2 ]
Khaw, Kay-tee [3 ]
机构
[1] Univ Cambridge, Dept Publ Hlth & Primary Care, Cambridge CB1 8RN, England
[2] MRC, Med Res Council Dunn Human Nutr Unit, Cambridge CB2 2XY, England
[3] Univ Cambridge, Clin Gerontol Unit, Cambridge CB2 2QQ, England
基金
英国医学研究理事会; 英国惠康基金;
关键词
acid-base balance; urine pH; potential renal acid load; European prospective investigation into cancer and nutrition; EPIC-Norfolk;
D O I
10.1017/S0007114507862350
中图分类号
R15 [营养卫生、食品卫生]; TS201 [基础科学];
学科分类号
100403 ;
摘要
Evidence exists that a more acidic diet is detrimental to bone health. Although more precise methods exist for measurement of acid-base balance, urine pH reflects acid-base balance and is readily measurable but has not been related to habitual dietary intake in general populations. The present study investigated the relationship between urine pH and dietary acid-base load (potential renal acid load; PRAL) and its contributory food groups (fruit and vegetables, meats, cereal and dairy foods). There were 22038 men and women aged 39-78 years living in Norfolk (UK) with casual urine samples and dietary intakes from the European Prospective Investigation into Cancer and Nutrition (EPIC)-Norfolk FFQ. A sub-study (n 363) compared pH in casual samples and 24 h urine and intakes from a 7d diary and the FFQ. A more alkaline diet (low PRAL), high fruit and vegetable intake and lower consumption of meat was significantly associated with a more alkaline urine pH before and after adjustment for age, BMI, physical activity and smoking habit and also after excluding for urinary protein, glucose, ketones, diagnosed high blood pressure and diuretic medication. In the sub-study the strongest relationship was found between the 24 h urine and the 7d diary. In conclusion, a more alkaline diet, higher fruit and vegetable and lower meat intake were related to more alkaline urine with a magnitude similar to intervention studies. As urine pH relates to dietary acid-base load its use to monitor change in consumption of fruit and vegetables, in individuals, warrants further investigation.
引用
收藏
页码:1335 / 1343
页数:9
相关论文
共 50 条
  • [41] Calcaneum broadband ultrasound attenuation relates to vegetarian and omnivorous diets differently in men and women: an observation from the European Prospective Investigation into Cancer in Norfolk (EPIC-Norfolk) population study
    Welch, A
    Bingham, S
    Camus, J
    Dalzell, N
    Reeve, J
    Day, N
    Khaw, KT
    OSTEOPOROSIS INTERNATIONAL, 2005, 16 (06) : 590 - 596
  • [42] Body iron stores and risk of type 2 diabetes: results from the European Prospective Investigation into Cancer and Nutrition (EPIC)-Potsdam study
    J. Montonen
    H. Boeing
    A. Steffen
    R. Lehmann
    A. Fritsche
    H.-G. Joost
    M. B. Schulze
    T. Pischon
    Diabetologia, 2012, 55 : 2613 - 2621
  • [43] Coffee and tea drinking in relation to the risk of differentiated thyroid carcinoma: results from the European Prospective Investigation into Cancer and Nutrition (EPIC) study
    Raul Zamora-Ros
    Muath A. Alghamdi
    Valerie Cayssials
    Silvia Franceschi
    Martin Almquist
    Joakim Hennings
    Maria Sandström
    Konstantinos K. Tsilidis
    Elisabete Weiderpass
    Marie-Christine Boutron-Ruault
    Bodil Hammer Bech
    Kim Overvad
    Anne Tjønneland
    Kristina E. N. Petersen
    Francesca Romana Mancini
    Yahya Mahamat-Saleh
    Fabrice Bonnet
    Tilman Kühn
    Renée T. Fortner
    Heiner Boeing
    Antonia Trichopoulou
    Christina Bamia
    Georgia Martimianaki
    Giovanna Masala
    Sara Grioni
    Salvatore Panico
    Rosario Tumino
    Francesca Fasanelli
    Guri Skeie
    Tonje Braaten
    Cristina Lasheras
    Elena Salamanca-Fernández
    Pilar Amiano
    Maria-Dolores Chirlaque
    Aurelio Barricarte
    Jonas Manjer
    Peter Wallström
    H. Bas Bueno-de-Mesquita
    Petra H. Peeters
    Kay-Thee Khaw
    Nicholas J. Wareham
    Julie A. Schmidt
    Dagfinn Aune
    Graham Byrnes
    Augustin Scalbert
    Antonio Agudo
    Sabina Rinaldi
    European Journal of Nutrition, 2019, 58 : 3303 - 3312
  • [44] Coffee and tea drinking in relation to the risk of differentiated thyroid carcinoma: results from the European Prospective Investigation into Cancer and Nutrition (EPIC) study
    Zamora-Ros, Raul
    Alghamdi, Muath A.
    Cayssials, Valerie
    Franceschi, Silvia
    Almquist, Martin
    Hennings, Joakim
    Sandstrom, Maria
    Tsilidis, Konstantinos K.
    Weiderpass, Elisabete
    Boutron-Ruault, Marie-Christine
    Hammer Bech, Bodil
    Overvad, Kim
    Tjonneland, Anne
    Petersen, Kristina E. N.
    Mancini, Francesca Romana
    Mahamat-Saleh, Yahya
    Bonnet, Fabrice
    Kuehn, Tilman
    Fortner, Renee T.
    Boeing, Heiner
    Trichopoulou, Antonia
    Bamia, Christina
    Martimianaki, Georgia
    Masala, Giovanna
    Grioni, Sara
    Panico, Salvatore
    Tumino, Rosario
    Fasanelli, Francesca
    Skeie, Guri
    Braaten, Tonje
    Lasheras, Cristina
    Salamanca-Fernandez, Elena
    Amiano, Pilar
    Chirlaque, Maria-Dolores
    Barricarte, Aurelio
    Manjer, Jonas
    Wallstrom, Peter
    Bueno-de-Mesquita, H. Bas
    Peeters, Petra H.
    Khaw, Kay-Thee
    Wareham, Nicholas J.
    Schmidt, Julie A.
    Aune, Dagfinn
    Byrnes, Graham
    Scalbert, Augustin
    Agudo, Antonio
    Rinaldi, Sabina
    EUROPEAN JOURNAL OF NUTRITION, 2019, 58 (08) : 3303 - 3312
  • [45] Body iron stores and risk of type 2 diabetes: results from the European Prospective Investigation into Cancer and Nutrition (EPIC)-Potsdam study
    Montonen, J.
    Boeing, H.
    Steffen, A.
    Lehmann, R.
    Fritsche, A.
    Joost, H. -G.
    Schulze, M. B.
    Pischon, T.
    DIABETOLOGIA, 2012, 55 (10) : 2613 - 2621
  • [46] A RISK SCORE TO IDENTIFY INDIVIDUALS AT HIGHER RISK OF INFLAMMATORY POLYARTHRITIS: RESULTS FROM THE EUROPEAN PROSPECTIVE INVESTIGATION OF CANCER (NORFOLK) AND THE NORFOLK ARTHRITIS REGISTER (THE EPIC-2-NOAR STUDY)
    Lahiri, M.
    Morgan, C.
    Luben, R. N.
    Bunn, D. K.
    Lunt, M.
    Verstappen, S. M.
    Symmons, D. P.
    Khaw, K. -T.
    Wareham, N. J.
    Bruce, I. N.
    ANNALS OF THE RHEUMATIC DISEASES, 2013, 71 : 68 - 69
  • [47] Differences in dietary intakes, food sources and determinants of total flavonoids between Mediterranean and non-Mediterranean countries participating in the European Prospective Investigation into Cancer and Nutrition (EPIC) study
    Zamora-Ros, Raul
    Knaze, Viktoria
    Lujan-Barroso, Leila
    Romieu, Isabelle
    Scalbert, Augustin
    Slimani, Nadia
    Hjartaker, Anette
    Engeset, Dagrun
    Skeie, Guri
    Overvad, Kim
    Bredsdorff, Lea
    Tjonneland, Anne
    Halkjaer, Jytte
    Key, Timothy J.
    Khaw, Kay-Tee
    Mulligan, Angela A.
    Winkvist, Anna
    Johansson, Ingegerd
    Bueno-de-Mesquita, H. Bas
    Peeters, Petra H. M.
    Wallstrom, Peter
    Ericson, Ulrika
    Pala, Valeria
    de Magistris, Maria Santucci
    Polidoro, Silvia
    Tumino, Rosario
    Trichopoulou, Antonia
    Dilis, Vardis
    Katsoulis, Michael
    Maria Huerta, Jose
    Martinez, Virginia
    Sanchez, Maria-Jose
    Ardanaz, Eva
    Amiano, Pilar
    Teucher, Birgit
    Grote, Verena
    Bendinelli, Benedetta
    Boeing, Heiner
    Foerster, Jana
    Touillaud, Marina
    Perquier, Florence
    Fagherazzi, Guy
    Gallo, Valentina
    Riboli, Elio
    Gonzalez, Carlos A.
    BRITISH JOURNAL OF NUTRITION, 2013, 109 (08) : 1498 - 1507
  • [48] Fruit and vegetable consumption and self-reported functional health in men and women in the European Prospective Investigation into Cancer-Norfolk (EPIC-Norfolk): a population-based cross-sectional study
    Myint, Phyo K.
    Welch, Ailsa A.
    Bingham, Sheila A.
    Surtees, Paul G.
    Wainwright, Nicholas W. J.
    Luben, Robert N.
    Wareham, Nicholas J.
    Smith, Richard D.
    Harvey, Ian M.
    Day, Nicholas E.
    Khaw, Kay-Tee
    PUBLIC HEALTH NUTRITION, 2007, 10 (01) : 34 - 41
  • [49] Intakes and sources of isoflavones, lignans, enterolignans, coumestrol and soya-containing foods in the Norfolk arm of the European Prospective Investigation into Cancer and Nutrition (EPIC-Norfolk), from 7 d food diaries, using a newly updated database
    Mulligan, Angela A.
    Kuhnle, Gunter G. C.
    Lentjes, Marleen A. H.
    van Scheltinga, Veronica
    Powell, Natasha A.
    McTaggart, Alison
    Bhaniani, Amit
    Khaw, Kay-Tee
    PUBLIC HEALTH NUTRITION, 2013, 16 (08) : 1454 - 1462
  • [50] Fruit and vegetable intakes, dietary antioxidant nutrients, and total mortality in Spanish adults: findings from the Spanish cohort of the European Prospective Investigation into Cancer and Nutrition (EPIC-Spain) (vol 85, pg 1634, 2007)
    Agudo, A.
    Cabrera, L.
    Amiano, P.
    AMERICAN JOURNAL OF CLINICAL NUTRITION, 2008, 88 (04): : 1181 - 1181