Urine pH is an indicator of dietary acid-base load, fruit and vegetables and meat intakes: results from the European Prospective Investigation into Cancer and Nutrition (EPIC)-Norfolk population study

被引:135
|
作者
Welch, Ailsa A. [1 ]
Mulligan, Angela [1 ]
Bingham, Sheila A. [2 ]
Khaw, Kay-tee [3 ]
机构
[1] Univ Cambridge, Dept Publ Hlth & Primary Care, Cambridge CB1 8RN, England
[2] MRC, Med Res Council Dunn Human Nutr Unit, Cambridge CB2 2XY, England
[3] Univ Cambridge, Clin Gerontol Unit, Cambridge CB2 2QQ, England
基金
英国医学研究理事会; 英国惠康基金;
关键词
acid-base balance; urine pH; potential renal acid load; European prospective investigation into cancer and nutrition; EPIC-Norfolk;
D O I
10.1017/S0007114507862350
中图分类号
R15 [营养卫生、食品卫生]; TS201 [基础科学];
学科分类号
100403 ;
摘要
Evidence exists that a more acidic diet is detrimental to bone health. Although more precise methods exist for measurement of acid-base balance, urine pH reflects acid-base balance and is readily measurable but has not been related to habitual dietary intake in general populations. The present study investigated the relationship between urine pH and dietary acid-base load (potential renal acid load; PRAL) and its contributory food groups (fruit and vegetables, meats, cereal and dairy foods). There were 22038 men and women aged 39-78 years living in Norfolk (UK) with casual urine samples and dietary intakes from the European Prospective Investigation into Cancer and Nutrition (EPIC)-Norfolk FFQ. A sub-study (n 363) compared pH in casual samples and 24 h urine and intakes from a 7d diary and the FFQ. A more alkaline diet (low PRAL), high fruit and vegetable intake and lower consumption of meat was significantly associated with a more alkaline urine pH before and after adjustment for age, BMI, physical activity and smoking habit and also after excluding for urinary protein, glucose, ketones, diagnosed high blood pressure and diuretic medication. In the sub-study the strongest relationship was found between the 24 h urine and the 7d diary. In conclusion, a more alkaline diet, higher fruit and vegetable and lower meat intake were related to more alkaline urine with a magnitude similar to intervention studies. As urine pH relates to dietary acid-base load its use to monitor change in consumption of fruit and vegetables, in individuals, warrants further investigation.
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页码:1335 / 1343
页数:9
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