Clinical and MRI outcome after autologous hematopoietic stem cell transplantation in MS

被引：71
|
作者：
Saiz, A
Blanco, Y
Carreras, E
Berenguer, J
Rovira, M
Pujol, T
Marín, P
Arbizu, T
Graus, F
机构：
[1] Univ Barcelona, Hosp Clin, Invest Biomed August Pi & Sunyer, Serv Neurol, Barcelona 08036, Spain
[2] Univ Barcelona, Hosp Clin, Invest Biomed August Pi & Sunyer, Bone Marrow Transplantat Unit,Serv Hematol, Barcelona 08036, Spain
[3] Univ Barcelona, Hosp Clin, Invest Biomed August Pi & Sunyer, Serv Radiol, Barcelona 08036, Spain
[4] Univ Barcelona, Hosp Clin, Invest Biomed August Pi & Sunyer, Blood Bank, Barcelona 08036, Spain
[5] Univ Barcelona, Hosp Clin, Invest Biomed August Pi & Sunyer, Cryopreservat Unit, Barcelona 08036, Spain
[6] CSU Bellvitge, Serv Neurol, Unidad Esclerosis Multiple, Lhospitalet De Llobregat, Barcelona, Spain
来源：
NEUROLOGY | 2004年 / 62卷 / 02期
关键词：
D O I：
10.1212/WNL.62.2.282
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
The authors report the outcome of 14 patients with severe multiple sclerosis treated with autologous hematopoietic stem cell transplantation (AHSCT) after a median follow-up period of 3 years. The 3-year actuarial probability of progression-free survival was 85.7% and that of disease activity-free survival was 46.4%. On MRI, no T1-enhanced lesions were detected after AHSCT. The mean change in T2 lesion volume from baseline to the third year was -20.2% and that of the corpus callosum area was -12.7%; 50% of this reduction was seen during the first year.
引用
收藏
页码：282 / 284
页数：3
相关论文
共 50 条
  • [1] MRI and CSF oligoclonal bands after autologous hematopoietic stem cell transplantation in MS
    Saiz, A
    Carreras, E
    Berenguer, J
    Yagüe, J
    Martínez, C
    Marín, P
    Rovira, M
    Pujol, T
    Arbizu, T
    Graus, F
    NEUROLOGY, 2001, 56 (08) : 1084 - 1089
  • [2] Autologous hematopoietic stem cell transplantation in secondary progressive MS: clinical, MRI and laboratory findings
    Saccardi, R
    Mancardi, G
    Bacigalupo, A
    Bosi, A
    Di Bartolomeo, P
    Donelli, A
    Gualandi, F
    La Nasa, G
    Murialdo, A
    Pagliai, F
    Papineschi, F
    Saglio, G
    Marmont, A
    BONE MARROW TRANSPLANTATION, 2002, 29 : S13 - S13
  • [3] Clinical outcome 6 years after autologous hematopoietic stem cell transplantation in multiple sclerosis
    Saiz, A.
    Blanco, Y.
    Berenguer, J.
    Gomez-Choco, M.
    Carreras, E.
    Arbizu, T.
    Graus, F.
    NEUROLOGIA, 2008, 23 (07): : 405 - 407
  • [4] Autologous hematopoietic stem cell transplantation suppresses Gd-enhanced MRI activity in MS
    Mancardi, GL
    Saccardi, R
    Filippi, M
    Gualandi, F
    Murialdo, A
    Inglese, M
    Marrosu, MG
    Meucci, G
    Massacesi, L
    Lugaresi, A
    Pagliai, F
    Sormani, MP
    Sardanelli, F
    Marmont, A
    NEUROLOGY, 2001, 57 (01) : 62 - 68
  • [5] Phenotypic shifts in immune cells after autologous hematopoietic stem cell transplantation for MS
    Mueller, Malin
    Nazir, Faisal Hayat
    Pavlovic, Ivan
    Wiberg, Anna
    Burman, Joachim
    MULTIPLE SCLEROSIS JOURNAL, 2023, 29 : 591 - 591
  • [6] Long term outcomes after autologous hematopoietic stem cell transplantation for treatment of MS
    Muraro, P. A.
    Pasquini, M.
    Atkins, H.
    Bowen, J.
    Farge, D.
    Fassas, A.
    Freedman, M. S.
    Georges, G. E.
    Gualandi, F.
    Hamerschlak, N.
    Havrdova, E.
    Kimiskidis, V. K.
    Kozak, T.
    Mancardi, G. L.
    Massacesi, L.
    Moraes, D.
    Nash, R. A.
    Pavletic, S.
    Ouyang, J.
    Rovira, M.
    Saiz, A.
    Simoes, B.
    Trneny, M.
    Zhu, L.
    Zhong, X.
    Badoglio, M.
    Sormani, M. P.
    Saccardi, R.
    MULTIPLE SCLEROSIS JOURNAL, 2015, 21 : 63 - 64
  • [7] Immunological Balance Is Associated with Clinical Outcome after Autologous Hematopoietic Stem Cell Transplantation in Type 1 Diabetes
    Malmegrim, Kelen C. R.
    de Azevedo, Julia T. C.
    Arruda, Lucas C. M.
    Abreu, Joana R. F.
    Couri, Carlos E. B.
    de Oliveira, Gislane L. V.
    Palma, Patricia V. B.
    Scortegagna, Gabriela T.
    Stracieri, Ana B. P. L.
    Moraes, Daniela A.
    Dias, Juliana B. E.
    Pieroni, Fabiano
    Cunha, Renato
    Guilherme, Luiza
    Santos, Nathalia M.
    Foss, Milton C.
    Covas, Dimas T.
    Burt, Richard K.
    Simoes, Belinda P.
    Voltarelli, Julio C.
    Roep, Bart O.
    Oliveira, Maria C.
    FRONTIERS IN IMMUNOLOGY, 2017, 8
  • [8] OUTCOME OF PATIENTS WITH NONSECRETORY MULTIPLE MYELOMA AFTER AUTOLOGOUS HEMATOPOIETIC STEM CELL TRANSPLANTATION
    Farhan, S.
    Lin, H.
    Baladandayuthapani, V.
    Shah, N.
    Bashir, Q.
    Hosing, C.
    Popat, U.
    Parmar, S.
    Dinh, Y.
    Qureshi, S.
    Rondon, G.
    Giralt, S.
    Champlin, R.
    Qazilbash, M.
    BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION, 2012, 18 (02) : S248 - S249
  • [9] Outcome of Patients With Nonsecretory Multiple Myeloma After Autologous Hematopoietic Stem Cell Transplantation
    Jacobs, Ryan W.
    Saliba, Rima M.
    Sasaki, Koji
    Farhan, Shatha
    Armas, Aristides
    Shah, Nina D.
    Bashir, Qaiser
    Qureshi, Sofia
    Rondon, Gabriela
    Hosing, Chitra
    Popat, Uday
    Parmar, Simrit
    Shah, Jatin J.
    Wang, Michael
    Weber, Donna M.
    Thomas, Sheeba K.
    Orlowski, Robert Z.
    Champlin, Richard E.
    Qazilbashi, Muzaffar H.
    CLINICAL LYMPHOMA MYELOMA & LEUKEMIA, 2016, 16 (01): : 36 - 42
  • [10] The hematopoietic cell transplantation comorbidity index predicts clinical outcomes after autologous stem cell transplantation
    Martinez-Roca, Alexandra
    Talarn Forcadell, Carme
    Gerardo Rodriguez-Lobato, Luis
    Escoda Teigell, Lourdes
    Vallansot, Rolando
    Cervera Calvo, Marta
    Do Nascimento, Janilson
    Aguinaco Culebras, Reyes
    Gimenez Perez, Teresa
    Araguas Arasanz, Carmen
    Vicent, Ana
    Sola, Maria
    Sarra Escarre, Josep
    BONE MARROW TRANSPLANTATION, 2018, 53 : 619 - 620
12345